Maslov A G, Karpov R S, Smirnov V P, Laptev B I, Metelkin A V
Lik Sprava. 1995 Jul-Aug(7-8):14-8.
A study was made of effects of transcardiac galvanization (TCG) on activities of a panel of oxidation-reduction enzymes as well as on the cardiac muscle content of high energy substrates, and size of the lesion area, in experimental myocardial infarction (EMI) in 50 albino male rats. After two TCG procedures, and at 24-h EMI, augmentation was found of activities of succinic dehydrogenase, lactate dehydrogenase, NADH-dehydrogenase, beta-hydroxybutyrate dehydrogenase, both in the area of profound ischemia and peri-infarction myocardium, this being accompanied with an increase in myocardial content of adenosine triphosphate, creatine phosphate, and glycogen, and reduction of the developing mass of necrosis. Stimulation of enzyme activity in the course on the enzyme complex and membrane-stabilizing action of this preformed physical factor.
对50只雄性白化大鼠实验性心肌梗死(EMI)模型进行经心腔电刺激(TCG),观察其对一组氧化还原酶活性、高能底物心肌含量及梗死面积的影响。经两次TCG处理后,在EMI发生24小时时,发现琥珀酸脱氢酶、乳酸脱氢酶、NADH脱氢酶、β-羟丁酸脱氢酶的活性在深度缺血区和梗死周边心肌均增强,同时伴有心肌三磷酸腺苷、磷酸肌酸和糖原含量增加,坏死范围缩小。这一预先形成的物理因子在酶复合物过程中刺激酶活性并具有膜稳定作用。