Risberg J, Passant U, Warkentin S, Gustafson L
Department of Psychogeriatrics, University Hospital, Lund, Sweden.
Dementia. 1993 May-Aug;4(3-4):186-7. doi: 10.1159/000107321.
Twenty-five out of 26 cases of autopsy-verified frontal lobe degeneration of non-Alzheimer type (FLD) were found to have focal frontal or frontotemporal blood flow reductions involving both hemispheres. The deviant case had an asymmetric frontal pathology only apparent on the right side. Focal reduction of blood flow in the frontal lobes is, however, a common and unspecific flow abnormality found in e.g. Pick's disease. Creutzfeldt-Jakob's disease, and in some cases of Alzheimer's disease. Low frontal flow has also been reported in schizophrenia and in toxic encephalopathy. Since a characteristic feature of FLD is a steady progress of the pathology, serial flow measurements extending over several years are especially informative.
在26例经尸检证实的非阿尔茨海默型额叶变性（FLD）病例中，有25例发现双侧半球额叶或额颞叶局部血流减少。唯一一例异常病例存在仅在右侧明显的不对称额叶病变。然而，额叶血流局部减少是一种常见的非特异性血流异常，例如在匹克氏病、克雅氏病以及某些阿尔茨海默病病例中都可发现。在精神分裂症和中毒性脑病中也有额叶血流降低的报道。由于FLD的一个特征是病情稳步进展，因此持续数年的系列血流测量尤其具有参考价值。
