Brun A
Neuropathology Division, University Hospital, Lund, Sweden.
Dementia. 1993 May-Aug;4(3-4):126-31. doi: 10.1159/000107311.
The neuropathology of frontal lobe degeneration of non-Alzheimer type was reevaluated on the basis of a new material of 13 cases against the background of experiences from earlier published 16 cases. The salient neuropathological feature was an unspecific neuronal degeneration of superficial cortical layers of the frontal and to some extent the temporal lobes without markers for Alzheimer's, Pick's or Lewy body diseases and there were no indications so far of a prion etiology. The consistency of histopathological features are taken to indicate a disease entity, also identified by other authors. It is tentatively grouped together with progressive and aphasic dementia, similar cases in the literature and possibly also Pick's disease and ALS with dementia.
基于13例新病例材料，并结合之前发表的16例病例的经验，对非阿尔茨海默型额叶变性的神经病理学进行了重新评估。显著的神经病理学特征是额叶及部分颞叶浅层皮质层出现非特异性神经元变性，无阿尔茨海默病、皮克病或路易体病的标志物，目前也没有朊病毒病因的迹象。组织病理学特征的一致性表明这是一种疾病实体，其他作者也有相同发现。它暂被归为进行性失语性痴呆、文献中类似病例，可能还包括皮克病以及伴有痴呆的肌萎缩侧索硬化症。
