Friedland R P, Koss E, Lerner A, Hedera P, Ellis W, Dronkers N, Ober B A, Jagust W J
Alzheimer Center, University Hospital of Cleveland, OH 44106.
Dementia. 1993 May-Aug;4(3-4):192-203. doi: 10.1159/000107323.
A 58-year-old man developed progressive difficulty with comprehension and verbal output with dementia. Positron emission tomography with 18F 2-fluoro-2-deoxy-D-glucose demonstrated asymmetrical frontal and anterior temporal lobe loss of glucose use. Scopolamine infusion (0.3 mg) did not influence memory. Postmortem studies revealed evidence of Pick's disease, with Pick bodies, loss of somatostatin, preservation of choline acetyltransferase and immunostaining with neurofilament antibodies. Pharmacological challenge and positron imaging offer valuable means for the noninvasive assessment of dementing illness. The contributions of functional imaging to our knowledge of frontal involvement in dementing illness are reviewed.
一名58岁男性出现进行性理解困难和伴有痴呆的言语输出障碍。18F 2-氟-2-脱氧-D-葡萄糖正电子发射断层扫描显示额叶和颞叶前部葡萄糖利用不对称性减少。输注东莨菪碱（0.3毫克）对记忆无影响。尸检研究发现匹克氏病的证据，有匹克小体、生长抑素缺失、胆碱乙酰转移酶保留以及神经丝抗体免疫染色。药理学激发试验和正电子成像为痴呆症的无创评估提供了有价值的手段。本文综述了功能成像对我们了解痴呆症中额叶受累情况的贡献。
