Kinane B T, Mansell A L, Zwerdling R G, Lapey A, Shannon D C
Pediatric Pulmonary Unit, Massachusetts General Hospital, Boston.
Chest. 1993 Oct;104(4):1183-6. doi: 10.1378/chest.104.4.1183.
Five patients in a pediatric population were identified with idiopathic follicular bronchitis (IFB) by open lung biopsy and their case records were reviewed. All were tachypneic and had a chronic cough by 6 weeks of age. The physical examination was characterized by diffuse fine crackles in four patients and by coarse rhonchi in one. The chest radiographs in all demonstrated a diffuse interstitial pattern. None had a collagen vascular or an autoimmune disease demonstrable. Response to corticosteroid therapy was minimal. Associated or coincidental esophageal reflux was treated surgically in two. No viral or bacterial agents were isolated in the sputum or the biopsy specimens. Patients have been followed up for 2 to 15 years; the conditions of all patients improved at about 2 to 4 years of age. The older patients have residual mild obstructive lung disease. To our knowledge, this is the first reported series of IFB in the pediatric population.
通过开胸肺活检在儿科人群中确诊了5例特发性滤泡性支气管炎（IFB）患者，并对其病历进行了回顾。所有患者均呼吸急促，6周龄时出现慢性咳嗽。体格检查发现，4例患者有弥漫性细湿啰音，1例有粗湿啰音。所有患者的胸部X线片均显示弥漫性间质病变。均未发现有可证实的胶原血管病或自身免疫性疾病。对皮质类固醇治疗反应甚微。2例患者因合并或巧合的食管反流接受了手术治疗。痰液或活检标本中未分离出病毒或细菌病原体。对患者进行了2至15年的随访；所有患者的病情在2至4岁左右有所改善。年龄较大的患者有残留的轻度阻塞性肺病。据我们所知，这是首次报道的儿科人群IFB系列病例。
