活动性溃疡性结肠炎中嗜中性粒细胞激活肽-1/白细胞介素-8的合成增强。
Enhanced synthesis of neutrophil-activating peptide-1/interleukin-8 in active ulcerative colitis.
作者信息
Mahida Y R, Ceska M, Effenberger F, Kurlak L, Lindley I, Hawkey C J
机构信息
Department of Therapeutics, University Hospital, Queen's Medical Centre, Nottingham, U.K.
出版信息
Clin Sci (Lond). 1992 Mar;82(3):273-5. doi: 10.1042/cs0820273.
PMID:1312411
Abstract
- We studied neutrophil-activating peptide-1/interleukin-8 in inflammatory bowel disease. 2. Mucosal levels of neutrophil-activating peptide-1/interleukin-8 were significantly higher in patients with active ulcerative colitis [median 74.5 (range 17.7-450.8) pg/mg] than in patients with active Crohn's disease [10.4 (4-46.9) pg/mg; P less than 0.002] or in normal control subjects [10.4 (4-16.6) pg/mg; P less than 0.002]. 3. Circulating neutrophil-activating peptide-1/interleukin-8 was generally undetectable but there were higher levels of anti-neutrophil-activating peptide-1/interleukin-8 antibodies in patients with active ulcerative colitis [62.9 (3.4-239) ng/ml] than in patients with active Crohn's disease [5.9 (2.1-18.10) ng/ml; P less than 0.001] or in control subjects [6.1 (3.2-15.8) ng/ml; P less than 0.001]. 4. Neutrophil-activating peptide-1/interleukin-8 may be of specific functional importance in mediating inflammation in ulcerative colitis.
摘要
- 我们研究了炎症性肠病中的中性粒细胞激活肽-1/白细胞介素-8。2. 活动性溃疡性结肠炎患者黏膜中的中性粒细胞激活肽-1/白细胞介素-8水平[中位数74.5（范围17.7 - 450.8）pg/mg]显著高于活动性克罗恩病患者[10.4（4 - 46.9）pg/mg；P < 0.002]或正常对照受试者[10.4（4 - 16.6）pg/mg；P < 0.002]。3. 循环中的中性粒细胞激活肽-1/白细胞介素-8通常检测不到，但活动性溃疡性结肠炎患者中抗中性粒细胞激活肽-1/白细胞介素-8抗体水平[62.9（3.4 - 239）ng/ml]高于活动性克罗恩病患者[5.9（2.1 - 18.10）ng/ml；P < 0.001]或对照受试者[6.1（3.2 - 15.8）ng/ml；P < 0.001]。4. 中性粒细胞激活肽-1/白细胞介素-8在介导溃疡性结肠炎炎症中可能具有特定的功能重要性。
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