恶性疟原虫疟疾患者中的抗磷脂抗体。
Anti-phospholipid antibodies in patients with Plasmodium falciparum malaria.
作者信息
Jakobsen P H, Morris-Jones S D, Hviid L, Theander T G, Høier-Madsen M, Bayoumi R A, Greenwood B M
机构信息
Centre for Medical Parasitology, University of Copenhagen, Denmark.
出版信息
Immunology. 1993 Aug;79(4):653-7.
Abstract
Plasma levels of antibodies against phosphatidylinositol (PI), phosphatidylcholine (PC) and cardiolipin (CL) were measured by enzyme-linked immunosorbent assay (ELISA) in patients from malaria endemic area of Sudan and The Gambia. Some Sudanese adults produced IgM antibodies against all three types of phospholipids (PL) during an acute Plasmodium falciparum infection. The anti-PL antibody titre returned to preinfection levels in most of the donors 30 days after the disease episode. IgG titres against PI, PC and CL were low. In Gambian children with malaria, IgM antibody titres against PI and PC were significantly higher in those with severe malaria than in those with mild malaria. These results show that a proportion of malaria patients produce anti-PL antibodies during infection and that titres of these antibodies are associated with the severity of disease.
摘要
通过酶联免疫吸附测定（ELISA）法，对来自苏丹和冈比亚疟疾流行地区的患者血浆中抗磷脂酰肌醇（PI）、磷脂酰胆碱（PC）和心磷脂（CL）的抗体水平进行了测量。一些苏丹成年人在急性恶性疟原虫感染期间产生了针对所有三种磷脂（PL）的IgM抗体。在疾病发作30天后，大多数献血者的抗PL抗体滴度恢复到感染前水平。针对PI、PC和CL的IgG滴度较低。在患有疟疾的冈比亚儿童中，患有严重疟疾的儿童针对PI和PC的IgM抗体滴度显著高于患有轻度疟疾的儿童。这些结果表明，一部分疟疾患者在感染期间会产生抗PL抗体，并且这些抗体的滴度与疾病的严重程度相关。
相似文献
1
Anti-phospholipid antibodies in patients with Plasmodium falciparum malaria.恶性疟原虫疟疾患者中的抗磷脂抗体。
Immunology. 1993 Aug;79(4):653-7.
2
High levels of anti-phospholipid antibodies in uncomplicated and severe Plasmodium falciparum and in P. vivax malaria.在无并发症的严重恶性疟原虫感染以及间日疟原虫感染中存在高水平的抗磷脂抗体。
Clin Exp Immunol. 1994 Feb;95(2):304-9. doi: 10.1111/j.1365-2249.1994.tb06528.x.
3
Pattern of humoral immune response to Plasmodium falciparum blood stages in individuals presenting different clinical expressions of malaria.呈现不同疟疾临床表现的个体对恶性疟原虫血液期的体液免疫反应模式。
Malar J. 2008 Sep 24;7:186. doi: 10.1186/1475-2875-7-186.
4
Patterns of anti-phospholipid antibody specificities.抗磷脂抗体特异性模式。
J Clin Lab Immunol. 1991 Jun;35(2):83-8.
5
Investigation of the kinetics of histidine-rich protein 2 and of the antibody responses to this antigen, in a group of malaria patients from India.对一组来自印度的疟疾患者体内富含组氨酸蛋白2的动力学以及针对该抗原的抗体反应的研究。
Ann Trop Med Parasitol. 2005 Sep;99(6):553-62. doi: 10.1179/136485905X51463.
6
Antibody reactivities to glutamate-rich peptides of Plasmodium falciparum parasites in humans from areas of different malaria endemicity.
APMIS. 1996 Oct;104(10):734-40. doi: 10.1111/j.1699-0463.1996.tb04936.x.
7
Differential regulation of IgG subclasses and IgE antimalarial antibody responses in complicated and uncomplicated Plasmodium falciparum malaria.恶性疟原虫复杂型和非复杂型疟疾中IgG亚类及IgE抗疟抗体反应的差异调节
Parasite Immunol. 2007 Sep;29(9):475-83. doi: 10.1111/j.1365-3024.2007.00965.x.
8
Distinct interethnic differences in immunoglobulin G class/subclass and immunoglobulin M antibody responses to malaria antigens but not in immunoglobulin G responses to nonmalarial antigens in sympatric tribes living in West Africa.生活在西非的同域部落中，对疟疾抗原的免疫球蛋白G类/亚类和免疫球蛋白M抗体反应存在明显的种族间差异，但对非疟疾抗原的免疫球蛋白G反应则不存在这种差异。
Scand J Immunol. 2005 Apr;61(4):380-6. doi: 10.1111/j.1365-3083.2005.01587.x.
9
Autoantibody against dendrite in Plasmodium falciparum infection: a singular auto-immune phenomenon preferentially in cerebral malaria.疟原虫感染中的树突抗体：一种在脑型疟疾中更倾向于出现的独特自身免疫现象。
Acta Trop. 2011 Apr;118(1):67-70. doi: 10.1016/j.actatropica.2011.01.005. Epub 2011 Feb 16.
10
Acquisition of antibodies to merozoite surface protein 3 among residents of Korogwe, north eastern Tanzania.坦桑尼亚东北部科罗戈韦居民中对裂殖子表面蛋白 3 的抗体获得情况。
BMC Infect Dis. 2010 Mar 8;10:55. doi: 10.1186/1471-2334-10-55.
引用本文的文献
1
Mechanism of Immune Evasion in Mosquito-Borne Diseases.蚊媒疾病中的免疫逃逸机制
Pathogens. 2023 Apr 23;12(5):635. doi: 10.3390/pathogens12050635.
2
Hyperoxidized Species of Heme Have a Potent Capacity to Induce Autoreactivity of Human IgG Antibodies.过氧化物物种的血红素有强烈的诱导人 IgG 抗体自身反应性的能力。
Int J Mol Sci. 2023 Feb 8;24(4):3416. doi: 10.3390/ijms24043416.
3
Oxidized hemoglobin triggers polyreactivity and autoreactivity of human IgG via transfer of heme.氧化血红蛋白通过血红素转移触发人 IgG 的多反应性和自身反应性。
Commun Biol. 2023 Feb 11;6(1):168. doi: 10.1038/s42003-023-04535-5.
4
The tangled web of autoreactive B cells in malaria immunity and autoimmune disease.疟原虫免疫和自身免疫性疾病中自身反应性 B 细胞的错综复杂网络。
Trends Parasitol. 2022 May;38(5):379-389. doi: 10.1016/j.pt.2022.01.005. Epub 2022 Feb 1.
5
Autoantibodies and Malaria: Where We Stand? Insights Into Pathogenesis and Protection.自身抗体与疟疾：我们目前的进展如何？对发病机制和保护作用的见解。
Front Cell Infect Microbiol. 2020 Jun 11;10:262. doi: 10.3389/fcimb.2020.00262. eCollection 2020.
6
Malaria and acute kidney injury.疟疾与急性肾损伤。
Pediatr Nephrol. 2020 Apr;35(4):603-608. doi: 10.1007/s00467-018-4191-0. Epub 2019 Jan 31.
7
Anti-Self Phosphatidylserine Antibodies Recognize Uninfected Erythrocytes Promoting Malarial Anemia.抗自身磷脂酰丝氨酸抗体识别未感染红细胞，促进疟疾贫血。
Cell Host Microbe. 2016 Feb 10;19(2):194-203. doi: 10.1016/j.chom.2016.01.009.
8
High antibody responses against Plasmodium falciparum in immigrants after extended periods of interrupted exposure to malaria.在长期中断疟疾接触后，移民对恶性疟原虫的抗体反应较高。
PLoS One. 2013 Aug 14;8(8):e73624. doi: 10.1371/journal.pone.0073624. eCollection 2013.
9
IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India.与细胞因子簇 II 相关的脑β微管蛋白 III 的 IgG 自身抗体可区分印度中部的脑型疟疾。
PLoS One. 2009 Dec 14;4(12):e8245. doi: 10.1371/journal.pone.0008245.
10
Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region.巴西亚马逊地区恶性疟原虫和间日疟原虫感染患者的细胞因子反应及贫血程度相似。
Clin Vaccine Immunol. 2008 Apr;15(4):650-8. doi: 10.1128/CVI.00475-07. Epub 2008 Feb 6.
本文引用的文献
1
Acylation of a Plasmodium falciparum merozoite surface antigen via sn-1,2-diacyl glycerol.通过sn-1,2-二酰甘油对恶性疟原虫裂殖子表面抗原进行酰化作用。
J Biol Chem. 1985 Apr 25;260(8):4969-74.
2
Identification of two integral membrane proteins of Plasmodium falciparum.恶性疟原虫两种整合膜蛋白的鉴定
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5195-9. doi: 10.1073/pnas.85.14.5195.
3
Induction of the proteolytic activity of a membrane protein in Plasmodium falciparum by phosphatidyl inositol-specific phospholipase C.磷脂酰肌醇特异性磷脂酶C诱导恶性疟原虫膜蛋白的蛋白水解活性
Nature. 1988 Mar 31;332(6163):457-9. doi: 10.1038/332457a0.
4
The specificity of anti-cardiolipin antibodies from syphilis patients and from patients with systemic lupus erythematosus.梅毒患者和系统性红斑狼疮患者抗心磷脂抗体的特异性。
Clin Exp Immunol. 1989 May;76(2):178-83.
5
Roles of tumour necrosis factor in the illness and pathology of malaria.肿瘤坏死因子在疟疾发病及病理过程中的作用。
Trans R Soc Trop Med Hyg. 1989 Jul-Aug;83(4):436-40. doi: 10.1016/0035-9203(89)90240-x.
6
Elevated tumor necrosis factor alpha and interleukin-6 serum levels as markers for complicated Plasmodium falciparum malaria.血清中肿瘤坏死因子α和白细胞介素-6水平升高作为重症恶性疟原虫疟疾的标志物。
Am J Med. 1989 Aug;87(2):139-43. doi: 10.1016/s0002-9343(89)80688-6.
7
Tumor necrosis factor and disease severity in children with falciparum malaria.恶性疟原虫疟疾患儿的肿瘤坏死因子与疾病严重程度
N Engl J Med. 1989 Jun 15;320(24):1586-91. doi: 10.1056/NEJM198906153202404.
8
Are bacterial endotoxins involved in autoimmunity by CD5+ (Ly-1+) B cells?CD5+（Ly-1+）B细胞介导的自身免疫反应中涉及细菌内毒素吗？
Immunol Today. 1989 Oct;10(10):334-6. doi: 10.1016/0167-5699(89)90189-8.
9
The malaria vaccine: anti-parasite or anti-disease?疟疾疫苗：抗寄生虫还是抗病？
Immunol Today. 1990 Jan;11(1):25-7. doi: 10.1016/0167-5699(90)90007-v.
10
Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H).抗磷脂抗体针对的是一种复合抗原，该抗原包括一种脂质结合的凝血抑制剂：β2-糖蛋白I（载脂蛋白H）。
Proc Natl Acad Sci U S A. 1990 Jun;87(11):4120-4. doi: 10.1073/pnas.87.11.4120.
Zotero 插件