Tripathi Y B, Pandey S, Shukla S D
Department of Medicinal Chemistry, Banras Hindu University, Varanasi, India.
Indian J Exp Biol. 1993 Jun;31(6):533-5.
Rubia cordifolia is clinically used for the purification of blood by the physicians of the Indian System of Medicine. For the first time, the effect of the partially purified fraction of this whole plant has been studied on rabbit platelets. It inhibits the platelet aggregation induced by PAF (platelet activating factor) but not thrombin. It also inhibits the binding of 3H-PAF to the platelets in the dose-dependent manner. Thus it appears that R. cordifolia inhibits action of PAF at its receptor level either by it's blocking or by desensitization.
印度传统医学的医生临床使用茜草来净化血液。首次研究了这种整株植物的部分纯化组分对兔血小板的作用。它抑制血小板活化因子（PAF）诱导的血小板聚集，但不抑制凝血酶诱导的血小板聚集。它还以剂量依赖的方式抑制3H-PAF与血小板的结合。因此，茜草似乎通过阻断或脱敏作用在PAF的受体水平抑制其作用。
