耐酸反应基因在鼠伤寒沙门氏菌毒力中的作用。
Role of acid tolerance response genes in Salmonella typhimurium virulence.
作者信息
Garcia-del Portillo F, Foster J W, Finlay B B
机构信息
Biotechnology Laboratory, University of British Columbia, Vancouver, Canada.
出版信息
Infect Immun. 1993 Oct;61(10):4489-92. doi: 10.1128/iai.61.10.4489-4492.1993.
Abstract
The atp and fur genes are involved in the acid tolerance response of Salmonella typhimurium. An atp::Tn10 mutant was avirulent in the mouse typhoid model when assayed by oral and intraperitoneal routes. However, a fur mutant was completely virulent by the intraperitoneal route. No relevant differences in intracellular survival or invasion rates were observed for the two mutants in macrophages and epithelial cells. These data indicate that separate acid tolerance response genes may have different roles in S. typhimurium virulence.
摘要
atp和fur基因参与鼠伤寒沙门氏菌的耐酸反应。当通过口服和腹腔途径检测时，一个atp::Tn10突变体在小鼠伤寒模型中无毒力。然而，一个fur突变体通过腹腔途径是完全有毒力的。在巨噬细胞和上皮细胞中，未观察到这两个突变体在细胞内存活或侵袭率方面的相关差异。这些数据表明，不同的耐酸反应基因在鼠伤寒沙门氏菌的毒力中可能具有不同的作用。
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