Lucas R M, Chen S Y, Aleo J J
J Periodontol. 1979 Jan;50(1):20-2. doi: 10.1902/jop.1979.50.1.20.
Endotoxin was found to be nonselective in its cytotoxicity of cellular organelles. All organelles studied displayed some degree of alteration which became more severe as the concentration of endotoxin was increased. The data suggest that the metabolism of the cell may be compromised at concentrations of endotoxin which do not affect cell viability. The problem involved in attempting to determine the actual concentration of endotoxin at the interface between the culture medium and the cell monolayer, in vitro, and the corresponding situation, in vivo, are also discussed.
研究发现内毒素对细胞器的细胞毒性没有选择性。所有研究的细胞器都表现出一定程度的改变，且随着内毒素浓度的增加，这种改变变得更加严重。数据表明，在内毒素浓度不影响细胞活力的情况下，细胞代谢可能会受到损害。本文还讨论了在体外试图确定培养基与细胞单层界面处内毒素的实际浓度以及在体内相应情况时所涉及的问题。
