一项关于卵胞浆内单精子注射（ICSI）与透明带下授精（SUZI）治疗严重男性因素不孕症的随机研究。

A randomized study of intracytoplasmic sperm injection (ICSI) versus subzonal insemination (SUZI) for the management of severe male-factor infertility.

作者信息

Levran D, Bider D, Yonesh M, Yemini Z, Seidman D S, Mashiach S, Dor J

机构信息

Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Israel.

出版信息

J Assist Reprod Genet. 1995 May;12(5):319-21. doi: 10.1007/BF02213711.

DOI:10.1007/BF02213711

PMID:8520195

Abstract

OBJECTIVE

Our objective was to compare the fertilization rates achieved by ICSI versus SUZI in couples with severe male infertility.

DESIGN

This was a randomized, prospective study.

SETTING

The study took place at the In-Vitro Fertilization-Embryo Transfer Unit, Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center.

MATERIALS AND METHODS

Oocytes of 12 patients were randomly allocated to either ICSI or SUZI procedures. Each woman thus served as her own control. All 12 patients had undergone at least two previous in vitro fertilization cycles with no fertilization or had a very low sperm count, i.e., a total motile sperm count of less than 0.5 x 10(6).

RESULTS

A total of 117 oocytes was obtained for fertilization. Of these oocytes, 16% (10/63) were successfully fertilized by SUZI, compared to 33% (18/54) treated by ICSI. This difference was statistically significant (P < 0.05). Of the 12 cycles, ICSI provided embryos in 10 cycles (83%), while SUZI was successful in only 6 cycles (50%). Four pregnancies were achieved: 33% per attempt, or 40% per transfer.

摘要

目的

我们的目的是比较严重男性不育夫妇中卵胞浆内单精子注射（ICSI）与精子输卵管内移植（SUZI）的受精率。

设计

这是一项随机前瞻性研究。

地点

该研究在海姆·谢巴医疗中心妇产科体外受精-胚胎移植科进行。

材料与方法

12例患者的卵母细胞被随机分配至ICSI或SUZI操作组。每位女性因此作为自身对照。所有12例患者此前至少经历过两个未受精的体外受精周期，或精子计数极低，即总活动精子计数少于0.5×10⁶。

结果

共获得117个用于受精的卵母细胞。其中，SUZI成功使16%（10/63）的卵母细胞受精，相比之下，ICSI处理的受精率为33%（18/54）。这一差异具有统计学意义（P<0.05）。在12个周期中，ICSI在10个周期（83%）中获得胚胎，而SUZI仅在6个周期（50%）中成功。共实现4次妊娠：每次尝试的妊娠率为33%，或每次移植的妊娠率为40%。