Driscoll M S, Grin-Jorgensen C M, Grant-Kels J M
Department of Medicine, University of Connecticut Health Center, Farmington 06030.
J Am Acad Dermatol. 1993 Oct;29(4):619-30. doi: 10.1016/0190-9622(93)70229-m.
The effect of pregnancy on the clinical course of malignant melanoma (MM) is unclear. Early clinical and laboratory evidence suggested a relation between hormones and MM and subsequently between pregnancy and MM. We reviewed the literature on MM and pregnancy to address three questions: What is the effect on prognosis if an MM is diagnosed during pregnancy? What is the effect of previous pregnancies on the prognosis of MM? What effect does a subsequent pregnancy have on the prognosis of MM? On the basis of a limited number of controlled studies, it does not appear that being pregnant before, after, or at the time of diagnosis of stage I MM influences the 5-year survival rate. However, caution in interpreting these data must be taken because it is possible that the duration of follow-up and size of the study populations are not sufficient to observe a true effect.
妊娠对恶性黑色素瘤（MM）临床病程的影响尚不清楚。早期的临床和实验室证据表明激素与MM之间存在关联，随后又表明妊娠与MM之间存在关联。我们回顾了关于MM与妊娠的文献，以探讨三个问题：如果在妊娠期间诊断出MM，对预后有何影响？既往妊娠对MM的预后有何影响？后续妊娠对MM的预后有何影响？基于数量有限的对照研究，似乎在I期MM诊断之前、之后或之时怀孕并不影响5年生存率。然而，在解释这些数据时必须谨慎，因为随访时间和研究人群规模可能不足以观察到真正的影响。
