McQuaid K R
J Clin Gastroenterol. 1993 Sep;17(2):97-100.
Nonulcer dyspepsia (NUD) is an enigmatic disorder which likely has heterogeneous etiologies. Helicobacter pylori-associated gastritis has been identified in a large number of patients with NUD, raising speculation that chronic infection with this organism may cause dyspepsia in some patients. Prospective case-control and cohort studies however do not suggest that H. pylori prevalence is greater in NUD than in asymptomatic controls. Limited therapeutic trials of H. pylori-eradication therapy have not shown a convincing symptomatic improvement compared with placebo treatment. Definition of the role of H. pylori in NUD awaits further well-designed, well-controlled epidemiologic and therapeutic studies. Until such information is available, routine endoscopic gastric biopsies looking for H. pylori in patients with NUD should be abandoned.
非溃疡性消化不良（NUD）是一种病因可能异质性的疑难病症。大量NUD患者中已发现幽门螺杆菌相关性胃炎，这引发了一种推测，即该生物体的慢性感染可能在某些患者中导致消化不良。然而，前瞻性病例对照研究和队列研究并未表明NUD患者中幽门螺杆菌的患病率高于无症状对照者。与安慰剂治疗相比，有限的幽门螺杆菌根除治疗试验并未显示出令人信服的症状改善。幽门螺杆菌在NUD中的作用的定义有待进一步精心设计、严格控制的流行病学和治疗研究。在获得此类信息之前，应放弃对NUD患者进行常规内镜胃活检以寻找幽门螺杆菌的做法。
