el-Naggar A K, Batsakis J G, Ordóñez N G, Luna M A, Goepfert H
Department of Pathology, University of Texas, M. D. Anderson Cancer Center, Houston.
J Laryngol Otol. 1993 Aug;107(8):716-20. doi: 10.1017/s0022215100124223.
We investigated the DNA ploidy patterns in thirteen primary and four recurrent rhabdomyosarcomas of the head and neck from thirteen adult patients and correlated the findings with other clinicopathological factors and clinical outcome. Twelve (92.7 per cent) of the primary neoplasms manifested an aneuploid DNA pattern, five had more than one stemline, and one neoplasm displayed a diploid DNA pattern. All recurrent lesions were DNA aneuploid with DNA indices (DIs) corresponding to their primary neoplasms. No correlation between the ploidy pattern and histological subtypes, tumour location, clinical stage and patient's clinical course was found. In this study, only two patients were long-term survivors. Both patients had stage I neoplasms that were located in non-parameningeal sites which manifested an alveolar histological pattern. Our data indicate that adult rhabdomyosarcomas of head and neck are preponderantly DNA aneuploid and are highly aggressive malignant neoplasms. Our results also suggest that tumours which are low stage and in a non-parameningeal location may pursue a less aggressive course.
我们研究了13例成年患者的13例原发性和4例复发性头颈部横纹肌肉瘤的DNA倍体模式，并将研究结果与其他临床病理因素及临床结局进行关联分析。12例（92.7%）原发性肿瘤表现为非整倍体DNA模式，5例有不止一个干系，1例肿瘤表现为二倍体DNA模式。所有复发性病变均为DNA非整倍体，其DNA指数（DI）与其原发性肿瘤相对应。未发现倍体模式与组织学亚型、肿瘤位置、临床分期及患者临床病程之间存在相关性。在本研究中，仅有2例患者为长期存活者。这2例患者的肿瘤均为I期，位于非脑膜旁部位，表现为腺泡状组织学模式。我们的数据表明，头颈部成人横纹肌肉瘤主要为DNA非整倍体，是具有高度侵袭性的恶性肿瘤。我们的结果还提示，低分期且位于非脑膜旁部位的肿瘤可能侵袭性较低。
