Markowitsch H J, Calabrese P, Liess J, Haupts M, Durwen H F, Gehlen W
University of Bielefeld, Germany.
J Neurol Neurosurg Psychiatry. 1993 Sep;56(9):988-92. doi: 10.1136/jnnp.56.9.988.
An industrial manager had severe retrograde and variable but usually mild anterograde amnesia four years after a head injury. MRI showed damage of both temporal poles and the lateral portion of the right prefrontal cortex. The prefrontal and temporal cortical damage on the right side extended deeply into the white matter while the temporal cortical damage on the left side was much smaller. There was an additional left temporo-parietal lesion. The patient was of average intelligence. His attention, short term memory and learning ability were average or somewhat below average. His old memories were severely affected for the personal-episodic domain and less so for semantic remote memory abilities. Therefore an anatomical dissociation between anterograde and retrograde amnesia is possible at the anterior temporal regions, possibly interacting with the prefrontal cortex; these regions seem necessary for the retrieval of old episodic memories.
一名工业经理在头部受伤四年后出现严重的逆行性遗忘，且遗忘情况多变，但顺行性遗忘通常较轻。磁共振成像（MRI）显示双侧颞极及右侧前额叶皮质外侧部分受损。右侧前额叶和颞叶皮质损伤深入白质，而左侧颞叶皮质损伤则小得多。此外还有左侧颞顶叶病变。患者智力中等。其注意力、短期记忆和学习能力处于中等水平或略低于中等水平。他的旧记忆在个人情节领域受到严重影响，语义性远期记忆能力受影响较小。因此，在前颞叶区域，顺行性遗忘和逆行性遗忘之间可能存在解剖学上的分离，可能与前额叶皮质相互作用；这些区域似乎是提取旧情节记忆所必需的。
