García Moncó J C, Wheeler C M, Benach J L, Furie R A, Lukehart S A, Stanek G, Steere A C
Department of Pathology, SUNY, Stony Brook 11794.
J Neurol Sci. 1993 Jul;117(1-2):206-14. doi: 10.1016/0022-510x(93)90175-x.
A subset of patients (50%) with neuroborreliosis (Lyme disease) showed IgG reactivity to cardiolipin in solid phase ELISA. In addition, a subset of patients with neuroborreliosis (29%) and syphilis (59%) had IgM reactivity to gangliosides with a Gal(beta 1-3) GalNac terminal sequence (GM1, GD1b, and asialo GM1). Anti-ganglioside IgM antibodies were significantly more frequent in these two groups of patients compared to patients with cutaneous and articular Lyme disease, primary antiphospholipid syndrome, systemic lupus erythematosus and normal controls. Correlative evidence and adsorption experiments indicated that antibodies to cardiolipin had separate specificities from those directed against the gangliosides. IgM antibodies to Gal(beta 1-3) GalNac gangliosides appeared to have similar specificities since these were positively correlated and inhibitable by cross adsorption assays. Given the clinical associations of patients with neuroborreliosis and syphilis with IgM reactivity to gangliosides sharing the Gal(beta 1-3) GalNac terminus, we suggest that these antibodies could represent a response to injury in neurological disease or a cross reactive event caused by spirochetes.
一部分神经莱姆病（莱姆病）患者（50%）在固相酶联免疫吸附测定中显示出对心磷脂的IgG反应性。此外，一部分神经莱姆病患者（29%）和梅毒患者（59%）对具有Gal(β1-3)GalNac末端序列的神经节苷脂（GM1、GD1b和脱唾液酸GM1）有IgM反应性。与皮肤和关节型莱姆病、原发性抗磷脂综合征、系统性红斑狼疮患者及正常对照相比，抗神经节苷脂IgM抗体在这两组患者中更为常见。相关证据和吸附实验表明，抗心磷脂抗体与抗神经节苷脂抗体具有不同的特异性。针对Gal(β1-3)GalNac神经节苷脂的IgM抗体似乎具有相似的特异性，因为它们呈正相关且可通过交叉吸附试验抑制。鉴于神经莱姆病和梅毒患者与对共享Gal(β1-3)GalNac末端的神经节苷脂具有IgM反应性之间的临床关联，我们认为这些抗体可能代表对神经疾病损伤的反应或由螺旋体引起的交叉反应事件。
