Lakka T A, Salonen J T
Research Institute of Public Health, University of Kuopio, Finland.
J Clin Epidemiol. 1993 Oct;46(10):1119-27. doi: 10.1016/0895-4356(93)90111-d.
A reduction of plasma fibrinogen has been suggested as one mechanism through which physical activity would protect against coronary heart disease (CHD). Therefore, we investigated the association of conditioning leisure time physical activity (CLTPA), assessed quantitatively by a 12-month history, and maximal oxygen uptake (VO2max) with plasma fibrinogen concentration in eastern Finnish men aged 42-60 years. A high mean intensity of CLTPA (standardized multivariate regression coefficient beta -0.059, p = 0.020) and a high maximal oxygen uptake (beta -0.163, p < 0.001) were associated with reduced plasma fibrinogen when adjusting for the strongest covariates. The adjusted relative difference in plasma fibrinogen concentration was 6.6% between men with a mean CLTPA intensity of < 4 and > 8 METs and 9.1% between the extreme quartiles of VO2max (< 2.21 vs > 2.961/min). The association between the mean intensity of CLTPA (p = 0.030 for interaction) and VO2max (p = 0.033) and plasma fibrinogen was stronger for smokers than for non-smokers. These data indicate that a reduction of plasma fibrinogen concentration may be one mechanism through which moderate to high intensity CLTPA and high cardiorespiratory fitness reduce the risk of CHD.
血浆纤维蛋白原水平降低被认为是体育活动预防冠心病（CHD）的一种机制。因此，我们调查了通过12个月运动史定量评估的休闲时间有规律体育活动（CLTPA）以及最大摄氧量（VO2max）与42至60岁芬兰东部男性血浆纤维蛋白原浓度之间的关联。在对最强协变量进行校正后，较高的CLTPA平均强度（标准化多元回归系数β为-0.059，p = 0.020）和较高的最大摄氧量（β为-0.163，p < 0.001）与血浆纤维蛋白原水平降低相关。CLTPA平均强度< 4 METs和> 8 METs的男性之间，血浆纤维蛋白原浓度的校正相对差异为6.6%；VO2max极端四分位数（< 2.21 vs > 2.96 l/min）之间的差异为9.1%。吸烟者中，CLTPA平均强度（交互作用p = 0.030）和VO2max（p = 0.033）与血浆纤维蛋白原之间的关联比非吸烟者更强。这些数据表明，血浆纤维蛋白原浓度降低可能是中高强度CLTPA和高心肺适能降低冠心病风险的一种机制。
