Schadendorf D, Worm M, Czarnetzki B M
Universitätsklinikum Rudolf Virchow, Dept. of Dermatology, FU, Berlin.
J Neurooncol. 1993 Apr;16(1):77-9. doi: 10.1007/BF01324838.
The prognosis of patients with malignant melanoma and brain metastases is poor. Therapy of brain metastases is difficult and mostly unsuccessful, with brain metastases being the predominant factor which determines overall survival. We report here on a patient whose brain metastases responded to DTIC + INF-gamma. We present a short summary on the different effects on INF-alpha and INF-gamma and reach the conclusion that clinical trials which combine DTIC and INF-gamma should be performed. Based on this observation, combinations including INF-alpha are not necessarily comparable to modalities which include INF-gamma.
恶性黑色素瘤伴脑转移患者的预后较差。脑转移瘤的治疗困难且大多不成功，脑转移是决定总体生存的主要因素。我们在此报告1例脑转移瘤对达卡巴嗪（DTIC）+γ干扰素（INF-γ）有反应的患者。我们简要总结了α干扰素（INF-α）和γ干扰素的不同作用，并得出结论，应开展将DTIC与INF-γ联合应用的临床试验。基于这一观察结果，包含INF-α的联合方案不一定与包含INF-γ的方案具有可比性。
