Tachiyashiki K, Imaizumi K
Department of Living and Health Sciences, Joetsu University of Education, Japan.
J Nutr Sci Vitaminol (Tokyo). 1993 Apr;39(2):163-76. doi: 10.3177/jnsv.39.163.
The effects of vegetable oils (soybean oil and coconut oil) and C18-unsaturated fatty acids (oleic acid, C18:1; linoleic acid, C18:2; linolenic acid, C18:3) on plasma ethanol levels in male rats (6 weeks old) were investigated. Vegetable oils decreased and delayed the peak of plasma ethanol concentration: a dose-response to vegetable oils was observed in the concentration and time to maximum concentration of plasma ethanol but no change in disappearance time. These phenomena were observed in two conditions: 1) oral administration of vegetable oils before oral intubation of ethanol and 2) simultaneous oral administration of vegetable oils and ethanol. Similar responses were obtained in three C18-unsaturated fatty acids. No changes in hepatic alcohol and aldehyde dehydrogenase isozyme (high Km and low Km) activities were observed. The remaining rate of ethanol in stomach was significantly higher with administration of vegetable oils or linoleic acid. A high negative correlation between the maximum plasma ethanol concentration and the remaining rate of ethanol in stomach was found. These results suggest that the slowing of the gastric emptying is a major mechanism for the decreasing and delaying effects on plasma ethanol levels by vegetable oils. The present paper also suggests that fatty acids may participate in the decreasing and delaying actions on the peak of plasma ethanol concentration by vegetable oils.
研究了植物油（大豆油和椰子油）以及C18不饱和脂肪酸（油酸，C18:1；亚油酸，C18:2；亚麻酸，C18:3）对雄性大鼠（6周龄）血浆乙醇水平的影响。植物油降低并延迟了血浆乙醇浓度的峰值：在血浆乙醇浓度及其达到最大浓度的时间方面观察到了对植物油的剂量反应，但消失时间没有变化。在两种情况下观察到了这些现象：1）在乙醇经口插管前口服植物油；2）植物油与乙醇同时口服。三种C18不饱和脂肪酸也得到了类似的反应。未观察到肝脏乙醇和醛脱氢酶同工酶（高Km和低Km）活性的变化。给予植物油或亚油酸后，胃中乙醇的残留率显著更高。发现血浆乙醇最大浓度与胃中乙醇残留率之间存在高度负相关。这些结果表明，胃排空减慢是植物油降低和延迟血浆乙醇水平的主要机制。本文还表明，脂肪酸可能参与了植物油对血浆乙醇浓度峰值的降低和延迟作用。
