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Br J Cancer. 1980 Apr;41(4):523-8. doi: 10.1038/bjc.1980.94.
2
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Misonidazole Neuropathy: a clinical, electrophysiological, and histological study.米索硝唑神经病变：一项临床、电生理及组织学研究。
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引用本文的文献

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J Neurooncol. 1983;1(2):115-23. doi: 10.1007/BF00182956.

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Applied electrophysiology in nerve and muscle disease [abridged].神经与肌肉疾病中的应用电生理学[节略版]
Proc R Soc Med. 1966 Oct;59(10):989-93. doi: 10.1177/003591576605901023.
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The degeneration of peripheral nerve fibers.周围神经纤维的变性。
J Neurol Neurosurg Psychiatry. 1950 May;13(2):89-105. doi: 10.1136/jnnp.13.2.89.
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The morphological basis for alterations in nerve conduction in peripheral neuropathy.周围神经病变中神经传导改变的形态学基础。
Proc R Soc Med. 1971 Mar;64(3):295-8. doi: 10.1177/003591577106400328.
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Serum concentration measurements in man of the radiosensitizer Ro-07-0582: some preliminary results.放射增敏剂Ro-07-0582在人体中的血清浓度测量：一些初步结果。
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A simple method for long-term drug infusion in mice: evaluation of guanazole as a model (38488).一种用于小鼠长期药物输注的简单方法：以胍唑作为模型的评估（38488）
Proc Soc Exp Biol Med. 1975 Jan;148(1):118-22. doi: 10.3181/00379727-148-38488.
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In vivo testing of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique.使用肺集落技术通过KHT小鼠肿瘤对缺氧放射增敏剂进行体内测试。
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Radiosensitizers of hypoxic cells in solid tumors.实体瘤中乏氧细胞的放射增敏剂
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Hypoxia-dependent reduction of 1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol by Chinese hamster ovary cells and KHT tumor cells in vitro and in vivo.中国仓鼠卵巢细胞和KHT肿瘤细胞在体外和体内对1-(2-硝基-1-咪唑基)-3-甲氧基-2-丙醇的缺氧依赖性还原作用
Cancer Res. 1976 Oct;36(10):3761-5.
9
Acrylamide autonomic neuropathy in the cat. Part 1. Neurophysiological and histological studies.猫的丙烯酰胺自主神经病变。第1部分。神经生理学和组织学研究。
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Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses.放射增敏剂Ro 07-0582的临床试验：多次给药的经验
Br J Cancer. 1977 May;35(5):567-79. doi: 10.1038/bjc.1977.90.

急性和慢性给予米索硝唑对小鼠周围神经电生理学的影响。

Effect of acute and chronic misonidazole administration on peripheral-nerve electrophysiology in mice.

作者信息

Conroy P J, Von Burg R, Penney D P, Passalacqua W, Sutherland R M

出版信息

Br J Cancer. 1980 Apr;41(4):523-8. doi: 10.1038/bjc.1980.94.

DOI:10.1038/bjc.1980.94
PMID:7387850
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2010284/
Abstract

I.p. administration at several dose levels over periods of up to 12 weeks, or continuous i.v. infusion of high doses of misonidazole (MISO) for 15 h, produced no significant change in peripheral nerve conduction velocity (NCV) and did not prevent the normal increase in NCV as the animals matured from 12 to 24 weeks of age. Peripheral NCV (sural nerve) was reduced in both MISO-treated and control mice with hind-limb tumour implants, presumably owing to physical pressure due to tumour growth. In addition, neither the medial nerves nor the tibial nerve in the normal limbs of the tumour-implanted, drug-treated animals showed any change. Consequently our earlier and present studies do not confirm the recent reports of changes in NCV following either acute or chronic MISO administration to mice.

摘要

腹腔注射不同剂量米索硝唑（MISO）长达12周，或连续静脉输注高剂量米索硝唑15小时，均未导致外周神经传导速度（NCV）出现显著变化，也未阻止动物从12周龄成熟至24周龄期间正常的神经传导速度增加。在后肢植入肿瘤的米索硝唑治疗组和对照组小鼠中，外周神经传导速度（腓肠神经）均降低，这可能是由于肿瘤生长造成的物理压迫所致。此外，植入肿瘤并接受药物治疗的动物正常肢体中的内侧神经和胫神经均未显示出任何变化。因此，我们之前和目前的研究均未证实近期关于对小鼠急性或慢性给予米索硝唑后神经传导速度发生变化的报道。