Romero R, Nores J, Mazor M, Sepulveda W, Oyarzun E, Parra M, Insunza A, Montiel F, Behnke E, Cassell G H
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut.
J Reprod Med. 1993 Jul;38(7):543-8.
The purpose of this study was to determine the prevalence and clinical significance of microbial invasion of the amniotic cavity during spontaneous parturition at term. Amniotic fluid was retrieved by transabdominal amniocentesis from 90 women in spontaneous term labor with intact membranes. Fluid was cultured for aerobic and anaerobic bacteria, including Mycoplasma. The prevalence of positive amniotic fluid cultures was 18.8% (17/90). The most common microbial isolates were Ureaplasma urealyticum, Streptococcus agalactiae, Lactobacillus species and Mycoplasma hominis. Clinical signs of chorioamnionitis were present in three patients, and only one of them had a positive amniotic fluid culture. Five patients (5.5%) had puerperal endometritis; three of them had an amniotic fluid culture positive for microorganisms. All neonates were free of clinical signs of infection. The data indicate that microbial invasion of the amniotic cavity occurs frequently during spontaneous labor at term, and it may be both the cause and the consequence of labor.
本研究的目的是确定足月自然分娩时羊膜腔微生物入侵的发生率及其临床意义。通过经腹羊膜腔穿刺术，从90例胎膜完整的足月自然分娩妇女中获取羊水。对羊水进行需氧菌和厌氧菌培养，包括支原体。羊水培养阳性率为18.8%（17/90）。最常见的微生物分离株为解脲脲原体、无乳链球菌、乳酸杆菌属和人型支原体。3例患者有绒毛膜羊膜炎的临床体征，其中只有1例羊水培养阳性。5例患者（5.5%）发生产褥期子宫内膜炎；其中3例羊水微生物培养阳性。所有新生儿均无感染的临床体征。数据表明，足月自然分娩期间羊膜腔微生物入侵频繁发生，它可能既是分娩的原因，也是分娩的结果。
