Fozzard H A
Prog Cardiovasc Dis. 1977 Mar-Apr;19(5):343-59. doi: 10.1016/0033-0620(77)90015-9.
The field of cellular cardiac electrophysiology has made excellent progress in the last decade in its effort to understand the electrical properties of the heart. It has profited from progress in membrane electrophysiology that has increased our understanding of the basic ionic mechanisms. It has developed quantitative methods for study of these mechanisms, in spite of the geometrical complexity of the heart. Indeed this complexity has added a richness and challenge to this area. We have shared with skeletal muscle the problem of electromechanical coupling. This review has discussed the present state of our knowledge of basic membrane mechanisms of importance in understanding normal and pathological function of heart muscle. It is intended to lay the groundwork for the following articles dealing with special aspects of cardiac electrophysiology. There is a continual interchange of ideas and concepts between applied and basic electrophysiology, and, as a result of this interchange, we can expect both areas to grow greatly in the coming years.
在过去十年里，细胞心脏电生理学领域在理解心脏电特性方面取得了显著进展。它受益于膜电生理学的进步，这增进了我们对基本离子机制的理解。尽管心脏的几何结构复杂，但它已经开发出了研究这些机制的定量方法。事实上，这种复杂性为该领域增添了丰富性和挑战性。我们与骨骼肌共同面临着机电耦合的问题。这篇综述讨论了我们目前对在理解心肌正常和病理功能中重要的基本膜机制的认识状态。它旨在为后续论述心脏电生理学特殊方面的文章奠定基础。应用电生理学和基础电生理学之间不断地进行思想和概念的交流，并且由于这种交流，我们可以预期这两个领域在未来几年都会有很大的发展。
