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高浓度非甾体类和甾体类抗炎药对前列腺素诱导的豚鼠离体回肠收缩的影响。

Effect of high concentrations of non-steroidal and steroidal antiinflammatory drugs on prostaglandin-induced contractions of the guinea-pig isolated ileum.

作者信息

Famaey J P, Fontaine J, Reuse J

出版信息

Prostaglandins. 1977 Jan;13(1):107-14. doi: 10.1016/0090-6980(77)90047-8.

DOI:10.1016/0090-6980(77)90047-8
PMID:841098
Abstract

In addition to their well-known effect at low concentrations on prostaglandin synthesis or their release and production, 11 non-steroidal antiinflammatory drugs and 4 antiinflammatory steroids exhibit at high concentrations a direct antagonism on certain prostaglandin actions. This is demonstrated on PGE1- and PGF2alpha-induced contractions of guinea-pig isolated ileum when compared to acetylcholine-induced contractions. This inhibitory effect is totally reversible after washing out the drugs from the organ bath.

摘要

除了它们在低浓度时对前列腺素合成、释放和产生的众所周知的作用外，11种非甾体抗炎药和4种抗炎类固醇在高浓度时对某些前列腺素作用表现出直接拮抗作用。与乙酰胆碱诱导的收缩相比，这在豚鼠离体回肠的PGE1和PGF2α诱导的收缩中得到了证明。从器官浴中洗去药物后，这种抑制作用完全可逆。

相似文献

1
Effect of high concentrations of non-steroidal and steroidal antiinflammatory drugs on prostaglandin-induced contractions of the guinea-pig isolated ileum.高浓度非甾体类和甾体类抗炎药对前列腺素诱导的豚鼠离体回肠收缩的影响。
Prostaglandins. 1977 Jan;13(1):107-14. doi: 10.1016/0090-6980(77)90047-8.
2
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An analysis of the inhibitory effects and of possible prostaglandin antagonism of steroid sex hormones in the guinea-pig ileum.豚鼠回肠中甾体性激素的抑制作用及可能的前列腺素拮抗作用分析
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引用本文的文献

1
Antagonism by fenamates of prostaglandin action in guinea-pig and human alimentary muscle.灭酸类药物对豚鼠和人体消化道肌肉中前列腺素作用的拮抗作用。
Br J Pharmacol. 1980 Mar;68(3):357-62. doi: 10.1111/j.1476-5381.1980.tb14548.x.
2
Dose and pH dependent effects of aspirin on guinea-pig ileum.阿司匹林对豚鼠回肠的剂量和pH依赖性作用。
Ir J Med Sci. 1984 Jan;153(1):11-6. doi: 10.1007/BF02940517.
3
Antagonism of prostanoid-induced contractions of rat gastric fundus muscle by SC-19220, sodium meclofenamate, indomethacin or trimethoquinol.
SC-19220、甲氯芬那酸钠、吲哚美辛或三甲醌醇对前列腺素诱导的大鼠胃底肌收缩的拮抗作用。
Br J Pharmacol. 1980;71(1):169-75. doi: 10.1111/j.1476-5381.1980.tb10922.x.
4
The effects of non-steroidal anti-inflammatory drugs on cholinergic and histamine-induced contractions of guinea-pig isolated ileum.非甾体抗炎药对豚鼠离体回肠胆碱能和组胺诱导收缩的影响。
Br J Pharmacol. 1977 Jun;60(2):165-71. doi: 10.1111/j.1476-5381.1977.tb07737.x.
5
The effects of antiinflammatory steroids on the response of the guinea-pig isolated ileum to acetylcholine, histamine, nicotine, 5-hydroxytryptamine and electrical stimulation.抗炎类固醇对豚鼠离体回肠对乙酰胆碱、组胺、尼古丁、5-羟色胺及电刺激反应的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1979 Nov;309(2):191-5. doi: 10.1007/BF00501228.
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J Clin Invest. 1979 May;63(5):1026-35. doi: 10.1172/JCI109371.