Pong S S, Levine L
Prostaglandins. 1977 Jan;13(1):65-71. doi: 10.1016/0090-6980(77)90043-0.
Oligomycin, antimycin, and 2,4-dinitrophenol, compounds that are known to inhibit oxidative phosphorylation by different mechanisms, inhibit the production of prostaglandins by serum-stimulated MC5-5 cells. The prostaglandin production that is stimulated by thrombin and bradykinin is inhibited by 2,4-dinitrophenol. Prostaglandin synthesis by MC5-5 cells from exogeneously-supplied arachidonic acid, however, is not affected by 2,4-dinitrophenol. Antimycin and 2,4-dinitrophenol also inhibit the serum-stimulated release of arachidonic acid from the cellular lipids, suggesting that it is the expression of phospholipase activity, a prerequisite for synthesis of prostaglandins by MC5-5 cells, that is dependent on oxidative phosphorylation.
寡霉素、抗霉素和2,4-二硝基苯酚是已知通过不同机制抑制氧化磷酸化的化合物，它们可抑制血清刺激的MC5-5细胞产生前列腺素。2,4-二硝基苯酚可抑制凝血酶和缓激肽刺激产生的前列腺素。然而，MC5-5细胞从外源供应的花生四烯酸合成前列腺素不受2,4-二硝基苯酚影响。抗霉素和2,4-二硝基苯酚也抑制血清刺激的细胞脂质中花生四烯酸的释放，这表明正是磷脂酶活性的表达（MC5-5细胞合成前列腺素的一个先决条件）依赖于氧化磷酸化。
