甲基胆蒽转化的小鼠BALB/3T3细胞产生前列腺素：细胞松弛素B的抑制作用

Prostaglandin production by methylcholanthrene-transformed mouse BALB/3T3: inhibition by cytochalasin B.

作者信息

Pong S S, Levine L

出版信息

Prostaglandins. 1976 Nov;12(5):803-9. doi: 10.1016/0090-6980(76)90054-x.

DOI:10.1016/0090-6980(76)90054-x

Abstract

Cytochalasin B inhibits the production of prostaglandins by serum-, thrombin-, and bradykinin-stimulated MC5-5 cells. The serum-stimulated release of arachidonic acid from cellular phospholipids also is inhibited. Cytochalasin B does not affect the cells' prostaglandin synthetase activity when exogenous arachidonic acid is present. Deacylation of phospholipids may be the step affected by cytochalasin B possibly as a result of disruption of microfilament organization. Colchicine and vinblastine, two drugs that can disrupt microtubule organization, do not inhibit prostaglandin production by cells.

摘要

细胞松弛素B可抑制血清、凝血酶和缓激肽刺激的MC5-5细胞产生前列腺素。血清刺激细胞磷脂释放花生四烯酸的过程也受到抑制。当存在外源性花生四烯酸时，细胞松弛素B不影响细胞的前列腺素合成酶活性。磷脂的脱酰作用可能是受细胞松弛素B影响的步骤，这可能是微丝组织被破坏的结果。秋水仙碱和长春碱这两种能够破坏微管组织的药物，不会抑制细胞产生前列腺素。

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Prostaglandin production by methylcholanthrene-transformed mouse BALB/3T3: inhibition by cytochalasin B.甲基胆蒽转化的小鼠BALB/3T3细胞产生前列腺素：细胞松弛素B的抑制作用

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