Xenakis A, Marcu I
Med Interne. 1977 Jan-Mar;15(1):79-83.
Ferrokinetics and life-span of erythrocytes were investigated with 59Fe and 51Cr respectively, in 15 children with thalassemia major, aged between 18 months and 15 years (five of which had been splenectomized), and in 8 children with hereditary spherocytosis aged between 12 and 14 years. In all cases studied with 59Fe there was low tracer incorporation in erythrocytes, but no correlation of this parameter to the amount of Hb F. The use of radioisotopes in studies of hemolytic disorders of children is stressed, primarily when splenectomy is considered. Investigation of ferrokinetics in thalassemic children is useful for monitoring advanced stages of the disease.
分别用59Fe和51Cr对15名年龄在18个月至15岁之间的重型地中海贫血患儿（其中5名已行脾切除术）以及8名年龄在12至14岁之间的遗传性球形红细胞增多症患儿进行了铁动力学和红细胞寿命研究。在所有用59Fe研究的病例中，红细胞示踪剂掺入率低，但该参数与Hb F量无相关性。强调了放射性同位素在儿童溶血性疾病研究中的应用，主要是在考虑行脾切除术时。对地中海贫血患儿进行铁动力学研究有助于监测疾病的晚期阶段。
