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人体中蠕虫寄生虫的免疫调节与逃避

Immunological modulation and evasion by helminth parasites in human populations.

作者信息

Maizels R M, Bundy D A, Selkirk M E, Smith D F, Anderson R M

机构信息

Wellcome Research Centre for Parasitic Infections, Department of Biology, Imperial College of Science, Technology and Medicine, London, UK.

出版信息

Nature. 1993 Oct 28;365(6449):797-805. doi: 10.1038/365797a0.

Abstract

Helminth parasites are highly prevalent in human communities in developing countries. In an endemic area an infected individual may harbour parasitic worms for most of his or her life, and the ability of these infections to survive immunological attack has long been a puzzle. But new techniques are starting to expose the diverse mechanisms by which these agents modulate or evade their hosts' defences, creating a dynamic interaction between the human immune system and the parasite population.

摘要

蠕虫寄生虫在发展中国家的人类群体中极为普遍。在地方病流行地区,受感染个体可能一生中大部分时间都携带寄生虫,而这些感染能够在免疫攻击中存活的能力长期以来一直是个谜。但新技术开始揭示这些病原体调节或逃避宿主防御的多种机制,从而在人类免疫系统与寄生虫群体之间形成了一种动态相互作用。

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