Ottman R, Hong S, Lipton R B
G.H. Sergievsky Center, School of Public Health, Columbia University, New York, NY 10032.
Neurology. 1993 Oct;43(10):1954-60. doi: 10.1212/wnl.43.10.1954.
This study evaluated the validity of family history data on severe headache and migraine obtained from adult probands with epilepsy in a family study of seizure disorders. We compared the probands' reports of severe headaches and migraines in their parents and full siblings with symptom-based diagnoses based on self-reports. Overall sensitivity was 48% for severe headache and 44% for migraine. When we used reports of severe headaches to screen for migraine headaches in the relatives, sensitivity was 56%. These results indicate that severe headache and migraine are underreported in family history interviews with first-degree relatives. To obtain accurate information on headaches in families for clinical practice and genetic research, direct interviews with each relative may be required.
本研究在一项癫痫症家族研究中，评估了从患有癫痫的成年先证者处获取的严重头痛和偏头痛家族史数据的有效性。我们将先证者关于其父母和同胞兄弟姐妹严重头痛和偏头痛的报告，与基于自我报告的症状诊断进行了比较。严重头痛的总体敏感度为48%，偏头痛为44%。当我们使用严重头痛报告来筛查亲属中的偏头痛时，敏感度为56%。这些结果表明，在与一级亲属进行的家族史访谈中，严重头痛和偏头痛的报告不足。为了在临床实践和基因研究中获取关于家族中头痛的准确信息，可能需要对每个亲属进行直接访谈。
