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[微粒的吸附作用]

[Persorption of microparticles].

作者信息

Volkheimer G

出版信息

Pathologe. 1993 Sep;14(5):247-52.

PMID:8415433
Abstract

Solid, hard microparticles, such as starch granules, pollen, cellulose particles, fibres and crystals, whose diameters are well into the micrometre range, are incorporated regularly and in considerable numbers from the digestive tract. Motor factors play an important part in the paracellular penetration of the epithelial cell layer. From the subepithelial region the microparticles are transported away via lymph and blood vessels. They can be detected in body fluids using simple methods: only a few minutes after oral administration they can be found in the peripheral blood-stream. We observed their passage into urine, bile, cerebrospinal fluid, the alveolar lumen, the peritoneal cavity, breast milk, and transplacentally into the fetal blood-stream. Since persorbed microparticles can embolise small vessels, this touches on microangiological problems, especially in the region of the CNS. The long-term deposit of embolising microparticles which consist of potential allergens or contaminants, or which are carriers of contaminants, is of immunological and environmental-technical importance. Numerous ready-made foodstuffs contain large quantities of microparticles capable of persorption.

摘要

固态的硬微粒,如淀粉颗粒、花粉、纤维素颗粒、纤维和晶体,其直径达微米范围,大量且规律地从消化道进入体内。动力因素在上皮细胞层的细胞旁渗透中起重要作用。微粒从上皮下区域经淋巴管和血管运走。使用简单方法就能在体液中检测到它们:口服后几分钟就能在周围血流中发现。我们观察到它们进入尿液、胆汁、脑脊液、肺泡腔、腹腔、母乳,并经胎盘进入胎儿血流。由于被吸收的微粒会栓塞小血管,这涉及微血管问题,尤其是在中枢神经系统区域。由潜在过敏原或污染物组成或携带污染物的栓塞性微粒的长期沉积具有免疫学和环境技术重要性。许多现成食品含有大量能够被吸收的微粒。

相似文献

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[Persorption of microparticles].[微粒的吸附作用]
Pathologe. 1993 Sep;14(5):247-52.
2
Nanoparticles and microparticles for drug and vaccine delivery.用于药物和疫苗递送的纳米颗粒和微粒。
J Anat. 1996 Dec;189 ( Pt 3)(Pt 3):503-5.
3
Uptake of inert microparticles in normal and immune deficient mice.正常小鼠和免疫缺陷小鼠对惰性微粒的摄取。
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[The phenomenon of persorption--history and facts].[渗透现象——历史与事实]
Z Arztl Fortbild (Jena). 1993 Mar 12;87(3):217-21.
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Passage of particles through the wall of the gastrointestinal tract.颗粒通过胃肠道壁。
Environ Health Perspect. 1974 Dec;9:215-25. doi: 10.1289/ehp.749215.
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A commentary on morphological and quantitative aspects of microparticle translocation across the gastrointestinal mucosa.关于微粒跨胃肠黏膜转运的形态学和定量方面的述评。
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Early intestinal microparticle uptake in the rat.大鼠早期肠道微粒摄取
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8
Intestinal absorption of PLAGA microspheres in the rat.大鼠体内PLAGA微球的肠道吸收情况
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Parameters influencing intestinal epithelial permeability and microparticle uptake in vitro.体外影响肠上皮通透性和微粒摄取的参数。
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Particle uptake and translocation across epithelial membranes.颗粒跨上皮膜的摄取与转运。
J Anat. 1996 Dec;189 ( Pt 3)(Pt 3):487-90.

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