Gupta P K, Dikshith T S, Datta K K
Toxicology. 1977 Feb;7(1):57-68. doi: 10.1016/0300-483x(77)90038-5.
Administration of Iomex, petroleum fraction, at a dose level of 1 ml/kg for a period of 4 weeks did not produce any toxic symptoms in albino rats. At higher doses, however, the animals showed high incidence of mortality, reduction in food and water intake and loss in body weight. At necropsy, lungs were found to be congested and intestines hyperaemic. Histopathological examination revealed slight abnormalities in lungs, liver and kidney. The absolute organ weights decreased (liver, kidney, heart, spleen, lung, gonad, brain and adrenal), whereas relative weights increased. There was a significant fall in total erythrocyte (RBC) and total leucocyte (WBC) counts and haemoglobin content (Hb) was reduced. Increased lymphocytes with correspondingly decreased neutrophils were also observed. Serum and liver transaminases (GOT and GTP) showed enhanced activity.
以1毫升/千克的剂量水平给白化大鼠注射石油馏分碘美克斯，持续4周，未产生任何中毒症状。然而，在较高剂量下，动物死亡率很高，食物和水摄入量减少，体重减轻。尸检时，发现肺部充血，肠道充血。组织病理学检查显示肺、肝和肾有轻微异常。绝对器官重量下降（肝、肾、心、脾、肺、性腺、脑和肾上腺），而相对重量增加。总红细胞（RBC）和总白细胞（WBC）计数显著下降，血红蛋白含量（Hb）降低。还观察到淋巴细胞增加，中性粒细胞相应减少。血清和肝转氨酶（GOT和GTP）活性增强。
