Franceschi S, Boyle P, Maisonneuve P, La Vecchia C, Burt A D, Kerr D J, MacFarlane G J
Epidemiology Unit, Aviano Cancer Center, Italy.
Crit Rev Oncog. 1993;4(1):25-52.
Thyroid cancer is one of the rarest forms of cancer, yet there are wide variations in the degree of malignancy, ranging from the most rapidly fatal to the relatively benign. This is almost entirely dependent on the histological type. Generally speaking, data available on changing trends of incidence and mortality are subject to reservation, dependent on the degree to which they have been influenced by changing diagnostic criteria and the precision of histopathological description. Nevertheless, there is evidence that mortality is slowly decreasing, while incidence is slowly increasing. The purpose of this review is to try to interpret the temporal trends of incidence and mortality rates for thyroid carcinoma in the last 3 decades in light of the problems arising from changes in diagnostic standards and histological classification regarding thyroid neoplasms. Attention is also drawn to the implications, from a public health viewpoint, of the present intensive detection and treatment of occult thyroid carcinomas.
甲状腺癌是最罕见的癌症形式之一，但其恶性程度差异很大，从最迅速致命到相对良性不等。这几乎完全取决于组织学类型。一般来说，关于发病率和死亡率变化趋势的现有数据存在保留意见，这取决于它们受诊断标准变化和组织病理学描述精度影响的程度。然而，有证据表明死亡率在缓慢下降，而发病率在缓慢上升。本综述的目的是根据甲状腺肿瘤诊断标准和组织学分类变化所产生的问题，试图解读过去30年甲状腺癌发病率和死亡率的时间趋势。同时也从公共卫生角度关注目前对隐匿性甲状腺癌的强化检测和治疗所带来的影响。
