Budden F H
Trans R Soc Trop Med Hyg. 1976;70(5-6):484-91. doi: 10.1016/0035-9203(76)90134-6.
In 1959 a population of 638 persons over the age of seven years, suffering from heavy endemic onchocerciasis in the Sudan-Savannah of West Africa was examined, and approximately half were allotted to a group for treatment with suramin (up to a total of 4-2 g for healthy adults). In 1973 and 1974 it was possible to re-examine 145 persons allotted to the treatment group and 118 persons allotted to the control group. Measurements were made of the incidence of new "eye lesions", the progress of pre-existing "eye-lesions" and the deterioration in visual acuity. These were greater in men than in women, and increased with age. They were also greater in persons who in 1959 had microfilariae in the anterior chamber, and particularly in those who had already developed "eye lesions". Severe reactions occurred in a significant proportion of patients who received suramin, and one died. However, these was less deterioration in the eyes of persons in the treated than in the control group.
1959年，对西非苏丹 - 萨赫勒地区638名7岁以上患有重度地方性盘尾丝虫病的人群进行了检查，大约一半的人被分配到用苏拉明治疗的组（健康成年人总量可达4.2克）。1973年和1974年，对分配到治疗组的145人和分配到对照组的118人进行了重新检查。对新“眼部病变”的发生率、原有“眼部病变”的进展情况以及视力下降情况进行了测量。这些情况在男性中比在女性中更严重，并且随着年龄增长而增加。在1959年眼前房中有微丝蚴的人，尤其是那些已经出现“眼部病变”的人，情况也更严重。接受苏拉明治疗的患者中有相当一部分出现了严重反应，有一人死亡。然而，治疗组患者眼睛的恶化程度低于对照组。
