人类免疫缺陷病毒感染患者身体成分的早期变化：四极体阻抗分析表明存在严重营养不良。

Early changes of body composition in human immunodeficiency virus-infected patients: tetrapolar body impedance analysis indicates significant malnutrition.

作者信息

Ott M, Lembcke B, Fischer H, Jäger R, Polat H, Geier H, Rech M, Staszeswki S, Helm E B, Caspary W F

机构信息

Department of Medicine, University Hospital, Johann Wolfgang Goethe-University, Frankfurt, Germany.

出版信息

Am J Clin Nutr. 1993 Jan;57(1):15-9. doi: 10.1093/ajcn/57.1.15.

DOI:10.1093/ajcn/57.1.15

PMID:8416658

Abstract

Total body water, body fat, body cell mass (BCM), extracellular mass (ECM), and the ECM-BCM ratio by impedance analysis were determined in 193 human immunodeficiency virus (HIV)-infected patients and 340 control subjects. Walter Reed (WR) classification was WR 2 in 26, WR 3-5 in 85, and WR 6 in 82 patients. Whereas resistance was increased, reactance and the phase angle were significantly reduced in all patient groups. Neither body weight nor body mass index (BMI) was affected in WR 2 patients, but BCM was reduced (31.9 +/- 4.3 vs 35.8 +/- 7.3 kg, P < 0.007) and ECM (31.2 +/- 4.4 vs 28.8 +/- 3.8 kg) as well as ECM-BCM ratio increased (0.99 +/- 0.14 vs 0.83 +/- 0.16, P < 0.001). In contrast to WR classification, diarrhea did not correspond with malnutrition. A loss of BCM (malnutrition) occurred already in otherwise symptomless HIV-infected patients (WR 2). This effect can be measured by tetrapolar impedence analysis but not by body weight or BMI.

摘要

通过阻抗分析测定了193例人类免疫缺陷病毒（HIV）感染患者和340例对照者的全身水含量、体脂、体细胞质量（BCM）、细胞外质量（ECM）以及ECM与BCM的比值。在患者中，沃尔特·里德（WR）分类为WR 2的有26例，WR 3 - 5的有85例，WR 6的有82例。所有患者组的电阻均升高，电抗和相角则显著降低。WR 2患者的体重和体重指数（BMI）均未受影响，但BCM降低（31.9±4.3 vs 35.8±7.3 kg，P<0.007），ECM（31.2±4.4 vs 28.8±3.8 kg）以及ECM与BCM的比值升高（0.99±0.14 vs 0.83±0.16，P<0.001）。与WR分类不同的是，腹泻与营养不良并不相关。在无症状的HIV感染患者（WR 2）中就已出现BCM丢失（营养不良）。这种影响可以通过四极阻抗分析检测到，而不能通过体重或BMI检测到。