Speert D P, Campbell M E, Davidson A G, Wong L T
Division of Infectious and Immunological Diseases, British Columbia's Children's Hospital, Vancouver, Canada.
J Infect Dis. 1993 Jan;167(1):226-9. doi: 10.1093/infdis/167.1.226.
Respiratory and fecal specimens from 111 patients with cystic fibrosis (CF) were cultured on 394 occasions to determine which site Pseudomonas aeruginosa colonizes first. By an enrichment and selection culture technique, P. aeruginosa was recovered from fecal cultures in 21 (42%) of 50 respiratory tract-positive patients but from only 3 (6.3%) of 48 respiratory tract-negative patients and from 1 (2.2%) of 45 control subjects. In 4 (22%) of the 18 patients who became culture-positive during the study, P. aeruginosa was recovered from a fecal specimen before respiratory colonization. Only 1 of these 4 became persistently colonized with P. aeruginosa in the respiratory tract; however, the serotype of the respiratory isolate was different from that of the fecal isolate. P. aeruginosa is recovered rarely from the feces of patients with CF who are culture-negative in the respiratory tract. In patients with CF, primary colonization with P. aeruginosa probably occurs in the respiratory tract.
对111例囊性纤维化（CF）患者的呼吸道和粪便标本进行了394次培养，以确定铜绿假单胞菌首先定植的部位。通过富集和选择培养技术，在50例呼吸道阳性患者中的21例（42%）粪便培养物中分离出铜绿假单胞菌，但在48例呼吸道阴性患者中仅3例（6.3%）分离出该菌，在45例对照受试者中仅1例（2.2%）分离出该菌。在研究期间培养转为阳性的18例患者中，有4例（22%）在呼吸道定植前从粪便标本中分离出铜绿假单胞菌。这4例中只有1例在呼吸道持续被铜绿假单胞菌定植；然而，呼吸道分离株的血清型与粪便分离株不同。在呼吸道培养阴性的CF患者粪便中很少分离出铜绿假单胞菌。在CF患者中，铜绿假单胞菌的初次定植可能发生在呼吸道。
