Speert D P, Campbell M E
J Hosp Infect. 1987 Jan;9(1):11-21. doi: 10.1016/0195-6701(87)90089-2.
Pseudomonas aeruginosa colonizes the respiratory tract of most older patients with cystic fibrosis. The means by which these bacteria are acquired and the risk for patient-to-patient spread among subjects with cystic fibrosis are poorly understood. We studied the spread of Ps. aeruginosa within a hospital environment. Pseudomonas was rarely recovered from the inanimate environment surrounding patients with cystic fibrosis or from hand or rectal cultures of patients who were colonized in the oropharynx. There was transient cross-colonization with Ps. aeruginosa between patients with cystic fibrosis sharing a hospital room in three of seven pairs studied. In all cases the "new" isolate was recoverable only once and was not found during a 2-year follow-up. Three of four sibling pairs with cystic fibrosis shared the same Ps. aeruginosa serotype(s). The risk of sustained cross-colonization by Ps. aeruginosa between patients with cystic fibrosis appears to be minimal, except under conditions of prolonged close contact.
铜绿假单胞菌定殖于大多数老年囊性纤维化患者的呼吸道。目前对于这些细菌的获取方式以及在囊性纤维化患者之间发生患者间传播的风险了解甚少。我们研究了铜绿假单胞菌在医院环境中的传播情况。在囊性纤维化患者周围的无生命环境中，或在口咽部定殖患者的手部或直肠培养物中，很少能分离出铜绿假单胞菌。在七对共用医院病房的囊性纤维化患者中，有三对出现了铜绿假单胞菌的短暂交叉定殖。在所有病例中，“新”分离株仅能被检出一次，且在两年的随访期间未再发现。四对患有囊性纤维化的兄弟姐妹中有三对携带相同血清型的铜绿假单胞菌。除了在长期密切接触的情况下，囊性纤维化患者之间被铜绿假单胞菌持续交叉定殖的风险似乎极小。
