不同地理位置正常男性血清钾浓度的差异。

Differences in serum potassium concentrations in normal men in different geographic locations.

作者信息

Reidenberg M M, Gu Z P, Lorenzo B, Coutinho E, Athayde C, Frick J, Alvarez F, Brache V, Emuveyan E E

机构信息

Department of Pharmacology and Medicine, Cornell University Medical College, New York, NY 10021.

出版信息

Clin Chem. 1993 Jan;39(1):72-5.

PMID:8419062

Abstract

Hypokalemia has been associated with the taking of gossypol, a potential oral antifertility drug for men. Because the frequency of this response differed in different parts of the world, this study was done to learn if "normal" serum [K+] also differed. [K+] was measured by flame photometry in serum from apparently normal men from Austria (n = 30), China (53), Brazil (100), the Dominican Republic (38), and the US (103), and in plasma from Nigerian men (82). The mean (SD) for [K+] in Chinese men, 3.82 (0.27) mmol/L, was lower than that in Brazilians [4.06 (0.29) mmol/L], Austrians [4.14 (0.44) mmol/L], Dominicans [4.37 (0.33) mmol/L], or Americans [4.38 (0.37) mmol/L]. Apparently there are regional differences in average serum [K+], with men in China having lower serum [K+] than men elsewhere. This may predispose them to hypokalemia.

摘要

低钾血症与服用棉酚有关，棉酚是一种对男性有潜在作用的口服抗生育药物。由于这种反应的发生率在世界不同地区有所不同，因此开展了本研究以了解“正常”血清[K⁺]是否也存在差异。通过火焰光度法对来自奥地利（n = 30）、中国（53）、巴西（100）、多米尼加共和国（38）和美国（103）的表面正常男性的血清以及来自尼日利亚男性（82）的血浆中的[K⁺]进行了测量。中国男性的[K⁺]均值（标准差）为3.82（0.27）mmol/L，低于巴西人[4.06（0.29）mmol/L]、奥地利人[4.14（0.44）mmol/L]、多米尼加人[4.37（0.33）mmol/L]或美国人[4.38（0.37）mmol/L]。显然，平均血清[K⁺]存在地区差异，中国男性的血清[K⁺]低于其他地区的男性。这可能使他们易患低钾血症。