Levy M
Department of Paediatrics, Hospital for Sick Children, Toronto, Canada.
Clin Pediatr (Phila). 1993 Jan;32(1):25-9. doi: 10.1177/000992289303200105.
Propylthiouracil (PTU) is widely used to treat patients with hyperthyroidism. In rare cases, this drug has been found to have severe toxic effects on the liver. The case of a 14-year-old girl treated with PTU for hyperthyroidism who developed jaundice, severe hepatocellular dysfunction, and hepatomegaly is reported. Her condition gradually deteriorated, and she developed paranoid ideation, profound lethargy, and peripheral edema. After three weeks of prednisone therapy, clinical and laboratory signs of improvement were observed. This patient was one of only five pediatric cases among the 16 reported cases of PTU liver toxicity reported to date. Her history and the fatal outcome in some reported cases demonstrate the high degree of sensitivity required to recognize this potential complication in patients treated with PTU, particularly since its immediate discontinuance and steroid-therapy intervention may lead to recovery.
丙硫氧嘧啶（PTU）被广泛用于治疗甲状腺功能亢进症患者。在罕见情况下，已发现该药物对肝脏有严重毒性作用。本文报告了一名14岁患有甲状腺功能亢进症的女孩，她接受PTU治疗后出现黄疸、严重肝细胞功能障碍和肝肿大。她的病情逐渐恶化，出现了偏执观念、深度嗜睡和外周水肿。泼尼松治疗三周后，观察到临床和实验室指标有所改善。该患者是迄今为止报告的16例PTU肝毒性病例中仅有的5例儿科病例之一。她的病史以及一些报告病例中的致命结局表明，在接受PTU治疗的患者中识别这种潜在并发症需要高度的敏感性，特别是因为立即停药和类固醇治疗干预可能会导致康复。
