Frahm J, Merboldt K D, Hänicke W
Max-Planck-Institut für Biophysikalische Chemie, Göttingen, Germany.
Magn Reson Med. 1993 Jan;29(1):139-44. doi: 10.1002/mrm.1910290126.
Functional activation maps of the human visual cortex were obtained at a spatial resolution almost two orders of magnitude better than achievable by positron emission tomography and within measuring times of a few seconds. Transient alterations in the concentration of paramagnetic deoxyhemoglobin were conveniently detected at 2.0-T with use of RF-spoiled FLASH MRI sequences employing gradient echo times of 6 to 60 ms and voxel sizes of 2.5 to 39 microliters.
人类视觉皮层的功能激活图是在空间分辨率比正电子发射断层扫描所能达到的分辨率几乎高两个数量级的情况下获得的，并且测量时间在几秒之内。利用射频扰相快速低角度激发（FLASH）磁共振成像序列，在2.0-T磁场下，通过使用6至60毫秒的梯度回波时间和2.5至39微升的体素大小，可方便地检测到顺磁性脱氧血红蛋白浓度的瞬态变化。
