Carroll J C, Schwaitzberg S D, Ucci A A, Schlesinger R M, Lauritzen D, Sant G R
Department of Urology, New England Medical Center Hospitals, Boston, Massachusetts.
Urology. 1993 Jan;41(1):34-7. doi: 10.1016/0090-4295(93)90240-b.
The biocompatibility of a new elastomeric-hydrogel matrix biomaterial for use as an intravasal occlusive device was assessed by inserting it into the vas deferens of dogs. The vas was removed and examined histologically after varying periods of time. The biomaterial resulted in total occlusion of the vas. Epithelial changes were limited to squamous metaplasia in areas adjacent to the implant. Changes in the subepithelium were minimal. This new material is biocompatible with the dog vas, and it has potential as an occlusive device for "reversible" vasectomy in men. Semen analysis studies are needed to assess the completeness and reversibility of the vasal occlusion achieved with this implant.
通过将一种新型弹性体 - 水凝胶基质生物材料插入犬的输精管，对其作为血管内闭塞装置的生物相容性进行了评估。在不同时间段后取出输精管并进行组织学检查。该生物材料导致输精管完全闭塞。上皮变化仅限于植入物相邻区域的鳞状化生。上皮下变化极小。这种新材料与犬输精管具有生物相容性，并且有潜力作为男性“可逆性”输精管切除术的闭塞装置。需要进行精液分析研究来评估用这种植入物实现的输精管闭塞的完整性和可逆性。
