胎盘白细胞介素-6的产生在宫内感染时会增强，但在分娩时不会。
Placental interleukin-6 production is enhanced in intrauterine infection but not in labor.
作者信息
Matsuzaki N, Taniguchi T, Shimoya K, Neki R, Okada T, Saji F, Nakayama M, Suehara N, Tanizawa O
机构信息
Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
出版信息
Am J Obstet Gynecol. 1993 Jan;168(1 Pt 1):94-7. doi: 10.1016/s0002-9378(12)90892-3.
OBJECTIVE
Because interleukin-6 is an important mediator in the host defense mechanism against infection and tissue damage, we studied the capacity of placentas with or without either labor or chorioamnionitis in the third trimester to produce interleukin-6.
STUDY DESIGN
The placental blocks were cultured, and their interleukin-6 titers were measured by a bioassay.
RESULTS
Placentas with labor produced a similar amount of interleukin-6 to placentas without labor. In contrast, placentas with chorioamnionitis produced much more interleukin-6 than the placentas with or without labor (p < 0.0001).
CONCLUSION
Placental interleukin-6 is thus surmised to participate in potentiation of the placental and fetomaternal defense mechanisms together with placental interleukin-1 during chorioamnionitis.
目的
由于白细胞介素-6是宿主抵御感染和组织损伤防御机制中的重要介质，我们研究了孕晚期有无分娩或绒毛膜羊膜炎的胎盘产生白细胞介素-6的能力。
研究设计
培养胎盘组织块，采用生物测定法测量其白细胞介素-6滴度。
结果
有分娩的胎盘产生的白细胞介素-6量与未分娩的胎盘相似。相比之下，有绒毛膜羊膜炎的胎盘产生的白细胞介素-6比有或无分娩的胎盘多得多（p<0.0001）。
结论
因此推测，在绒毛膜羊膜炎期间，胎盘白细胞介素-6与胎盘白细胞介素-1一起参与增强胎盘和母胎防御机制。
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