Marini J J, Crooke P S
Department of Medicine, University of Minnesota, Minneapolis/St. Paul.
Am Rev Respir Dis. 1993 Jan;147(1):14-24. doi: 10.1164/ajrccm/147.1.14.
We have developed and validated a general mathematical model for the dynamic behavior of the single-compartment respiratory system in response to an arbitrary waveform of applied inspiratory pressure. Our general model for ventilation applies to all integrable functions of applied pressure, and it enables computation of most ventilation and pressure variables of clinical interest from clinician-selected and impedance-determined inputs readily measured or estimated at the bedside. Interactions between both phases of the ventilatory cycle are considered by assuming that deflation occurs passively from a unicompartment lung. Because this flexible model appears both capable of accurate prediction and robust to major violations of its underlying linear assumptions, it may prove to be of value in a variety of scientific, educational, and clinical settings.
我们已经开发并验证了一个用于单室呼吸系统动态行为的通用数学模型，该模型可响应任意波形的吸气压力。我们的通用通气模型适用于所有可积的施加压力函数，并且能够根据临床医生选择的以及通过在床边易于测量或估计的阻抗确定的输入，计算出大多数具有临床意义的通气和压力变量。通过假设单室肺被动发生呼气，考虑了通气周期两个阶段之间的相互作用。由于这个灵活的模型似乎既能够进行准确预测，又对其基本线性假设的重大违背具有鲁棒性，所以它可能在各种科学、教育和临床环境中都具有价值。
