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大鼠CINC（细胞因子诱导的中性粒细胞趋化因子）是人类GRO蛋白的同源物，但由单个基因编码。

Rat CINC (cytokine-induced neutrophil chemoattractant) is the homolog of the human GRO proteins but is encoded by a single gene.

作者信息

Zagorski J, DeLarco J E

机构信息

Department of Health Sciences, Monsanto Company, St. Louis, MO 63167.

出版信息

Biochem Biophys Res Commun. 1993 Jan 15;190(1):104-10. doi: 10.1006/bbrc.1993.1017.

DOI:10.1006/bbrc.1993.1017
PMID:8422237
Abstract

Human GRO and rat CINC proteins are members of the pro-inflammatory "chemokine" superfamily of chemotactic cytokines which includes IL-8. We have used Northern and Southern blot analyses to compare the expression of CINC-related and GRO transcripts in human cells and to compare the hybridization patterns of CINC and GRO probes in human and rat genomic DNA. Our data indicate that rat CINC is encoded by a single gene unlike GRO-alpha, -beta and -gamma which are encoded by three distinct genes and that they are the nearest homologs to each other from their respective species.

摘要

人GRO蛋白和大鼠CINC蛋白是促炎性趋化细胞因子“趋化因子”超家族的成员，该家族包括白细胞介素-8。我们利用Northern和Southern印迹分析来比较人细胞中CINC相关转录本和GRO转录本的表达，并比较人及大鼠基因组DNA中CINC和GRO探针的杂交模式。我们的数据表明，大鼠CINC由单个基因编码，这与由三个不同基因编码的GRO-α、-β和-γ不同，并且它们是各自物种中彼此最接近的同源物。

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1
Rat CINC (cytokine-induced neutrophil chemoattractant) is the homolog of the human GRO proteins but is encoded by a single gene.大鼠CINC（细胞因子诱导的中性粒细胞趋化因子）是人类GRO蛋白的同源物，但由单个基因编码。
Biochem Biophys Res Commun. 1993 Jan 15;190(1):104-10. doi: 10.1006/bbrc.1993.1017.
2
Investigation of possible autocrine functions for rat GRO/CINC (cytokine-induced neutrophil chemoattractant).大鼠GRO/CINC（细胞因子诱导的中性粒细胞趋化因子）自分泌功能的研究
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The production of CINC/gro, a member of the interleukin-8 family, in rat anterior pituitary gland.大鼠垂体前叶中白细胞介素-8家族成员CINC/gro的产生。
Biochem Biophys Res Commun. 1994 Jul 15;202(1):161-7. doi: 10.1006/bbrc.1994.1907.
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Glucocorticoid-mediated gene suppression of rat cytokine-induced neutrophil chemoattractant CINC/gro, a member of the interleukin-8 family, through impairment of NF-kappa B activation.糖皮质激素通过损害核因子κB的激活，介导对大鼠细胞因子诱导的中性粒细胞趋化因子CINC/gro（白细胞介素-8家族的一员）基因的抑制。
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Cytokine-induced expression of mRNAs for chemotactic factors in human synovial cells and fibroblasts.细胞因子诱导人滑膜细胞和成纤维细胞中趋化因子mRNA的表达。
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In vitro effects of CINC/gro, a member of the interleukin-8 family, on interleukin-6 secretion by rat posterior pituitary cells.
Biochem Biophys Res Commun. 1994 Apr 29;200(2):742-8. doi: 10.1006/bbrc.1994.1513.

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