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[地巴唑对实验性脑出血脑血流量及脑电图的影响]

[Effect of dibazol on cerebral blood supply and EEG in experimental intracerebral hemorrhage].

作者信息

Saratikov A S, Plotnikov M B, Plotnikova T M

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1977;77(1):56-8.

PMID:842228
Abstract

A hemorrhage into the right internal capsule in vigilant cats is accompanied by a drop of focal cerebral blood flow in the sensomotor cortex, in the thalamus and reticular formation of the middle brain of both hemispheres, an appearance of slow-wave high amplitude in the EEG activity and in some cases of convulsive discharges. Such changes of the blood flow and bioelectrical activity are preserved in survived cats after 24 hours following hemorrhage. An intracarotid singular injection (Img/kg) and especially a 30 minute infusion of 0.5% solution of dibasol brings about in most of the cases an increase of the blood flow in the studied brain structures, and is accompanied by a partial normalization of bioelectrical activity.

摘要

在警觉的猫中,右侧内囊出血伴随着双侧大脑感觉运动皮层、丘脑以及中脑网状结构局部脑血流量下降,脑电图活动出现高幅慢波,部分病例出现惊厥放电。出血后24小时存活的猫中,这种血流和生物电活动的变化依然存在。颈内动脉单次注射(1毫克/千克),尤其是30分钟输注0.5%的地巴唑溶液,在大多数情况下可使所研究脑区的血流量增加,并伴有生物电活动的部分恢复正常。

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