Pettitt D J, Knowler W C, Bennett P H, Aleck K A, Baird H R
Diabetes Care. 1987 Jan-Feb;10(1):76-80. doi: 10.2337/diacare.10.1.76.
The relationships of birth weight and maternal diabetes to the development of obesity were examined at 5-19 yr of age in the offspring of Pima Indian women. At each age, offspring of diabetic women, even those who were of normal birth weight, had a higher mean weight relative to height than offspring of nondiabetic and prediabetic women. Birth weight was predictive of relative weight in 5- to 9- and 10- to 14-yr-old offspring of nondiabetic women but not in the oldest group. In contrast, for offspring of prediabetic and diabetic women, birth weight was not predictive of subsequent obesity at any age studied. Offspring of diabetic women were heavier than offspring of nondiabetic and prediabetic women regardless of birth weight. Thus, maternal diabetes was important in predicting body size in the offspring even after accounting for the effects of the birth weight and maternal body size.
在皮马印第安女性的后代中，研究了出生体重和母亲患糖尿病与肥胖症发展之间的关系，研究对象为5至19岁的后代。在每个年龄段，糖尿病女性的后代，即使是那些出生体重正常的后代，相对于身高的平均体重都高于非糖尿病和糖尿病前期女性的后代。出生体重可预测非糖尿病女性5至9岁和10至14岁后代的相对体重，但对年龄最大的那组后代则无此预测作用。相比之下，对于糖尿病前期和糖尿病女性的后代，在所研究的任何年龄，出生体重都无法预测其随后是否会肥胖。糖尿病女性的后代比非糖尿病和糖尿病前期女性的后代更重，无论出生体重如何。因此，即使在考虑了出生体重和母亲体型的影响之后，母亲患糖尿病对于预测后代的体型仍很重要。
