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肿瘤突变P35B产生一种新抗原肽的MHC结合位点。

Tum- mutation P35B generates the MHC-binding site of a new antigenic peptide.

作者信息

Szikora J P, Van Pel A, Boon T

机构信息

Ludwig Institute for Cancer Research, Brussels, Belgium.

出版信息

Immunogenetics. 1993;37(2):135-8. doi: 10.1007/BF00216837.

DOI:10.1007/BF00216837
PMID:8423052
Abstract

Immunogenic tumor cell variant P35 was obtained by mutagen treatment of mouse mastocytoma P815. It expresses a potent new antigen recognized by syngeneic cytolytic T lymphocytes (CTL). This antigen is the result of a point mutation in a gene that is expressed by most healthy cells. A decapeptide encoded by the region spanning the mutation sensitized P815 cells to the relevant CTL, whereas the homologous decapeptide corresponding to the normal sequence did not. Only the mutant decapeptide was capable of enhancing the expression of the Dd-presenting molecule at the cell surface, indicating that the mutation generates a motif which enables the antigenic peptide to bind to Dd.

摘要

免疫原性肿瘤细胞变体P35是通过对小鼠肥大细胞瘤P815进行诱变处理获得的。它表达一种强效新抗原，可被同基因细胞溶解T淋巴细胞（CTL）识别。该抗原是大多数健康细胞所表达基因中一个点突变的结果。由跨越该突变区域编码的十肽使P815细胞对相关CTL敏感，而对应正常序列的同源十肽则无此作用。只有突变十肽能够增强细胞表面Dd呈递分子的表达，这表明该突变产生了一个基序，使抗原肽能够与Dd结合。

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1
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Immunogenetics. 1993;37(2):135-8. doi: 10.1007/BF00216837.
2
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Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. IV. Analysis of variant-specific antigens by selection of antigen-loss variants with cytolytic T cell clones.通过对小鼠肥大细胞瘤P815进行诱变获得的免疫原性变体。IV. 用细胞溶解T细胞克隆选择抗原缺失变体分析变体特异性抗原。
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本文引用的文献

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Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. II. T lymphocyte-mediated cytolysis.通过对小鼠肥大细胞瘤P815进行诱变获得的免疫原性变体。II. T淋巴细胞介导的细胞溶解作用。
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Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. I. Rejection by syngeneic mice.通过对小鼠肥大细胞瘤P815进行诱变获得的免疫原性变体。I. 同基因小鼠的排斥反应。
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一种突变的β-连环蛋白基因编码一种被肿瘤浸润淋巴细胞识别的黑色素瘤特异性抗原。
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H-2Dd exploits a four residue peptide binding motif.H-2Dd利用一个四残基肽结合基序。
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Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. III. Clonal analysis of the syngeneic cytolytic T lymphocyte response.通过对小鼠肥大细胞瘤P815进行诱变获得的免疫原性变体。III. 同基因细胞溶解型T淋巴细胞反应的克隆分析。
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Selection of highly transfectable variant from mouse mastocytoma P815.从小鼠肥大细胞瘤P815中筛选高转染性变体。
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6
Immunogenic (tum-) variants of mouse tumor P815: cloning of the gene of tum- antigen P91A and identification of the tum- mutation.小鼠肿瘤P815的免疫原性（肿瘤）变体：肿瘤抗原P91A基因的克隆及肿瘤突变的鉴定
Proc Natl Acad Sci U S A. 1988 Apr;85(7):2274-8. doi: 10.1073/pnas.85.7.2274.
7
Association of class I major histocompatibility heavy and light chains induced by viral peptides.病毒肽诱导的I类主要组织相容性重链和轻链的关联
Nature. 1989 Aug 10;340(6233):443-8. doi: 10.1038/340443a0.
8
Structure of the gene of tum- transplantation antigen P91A: the mutated exon encodes a peptide recognized with Ld by cytolytic T cells.肿瘤移植抗原P91A基因的结构：突变外显子编码一种可被细胞溶解T细胞与Ld识别的肽段。
Cell. 1989 Jul 28;58(2):293-303. doi: 10.1016/0092-8674(89)90844-1.
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Structural requirements for class I MHC molecule-mediated antigen presentation and cytotoxic T cell recognition of an immunodominant determinant of the human immunodeficiency virus envelope protein.I类主要组织相容性复合体（MHC）分子介导的抗原呈递及细胞毒性T细胞对人类免疫缺陷病毒包膜蛋白免疫显性决定簇识别的结构要求
J Exp Med. 1989 Dec 1;170(6):2023-35. doi: 10.1084/jem.170.6.2023.
10
Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes.布雷菲德菌素A特异性抑制蛋白质抗原向细胞毒性T淋巴细胞的呈递。
Science. 1989 Jun 2;244(4908):1072-5. doi: 10.1126/science.2471266.