类风湿关节炎女性发病前的生育力。
Fecundity before disease onset in women with rheumatoid arthritis.
作者信息
Nelson J L, Koepsell T D, Dugowson C E, Voigt L F, Daling J R, Hansen J A
机构信息
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
出版信息
Arthritis Rheum. 1993 Jan;36(1):7-14. doi: 10.1002/art.1780360103.
OBJECTIVE
To examine fecundity prior to disease onset in women with rheumatoid arthritis (RA).
METHODS
Two hundred fifty-nine RA patients with an opportunity for pregnancy were compared with 1,258 control women as part of a prospective case-control study of recent-onset RA in women.
RESULTS
A 12-month or longer interval to pregnancy was found in 42% of RA cases compared with 34% of controls (odds ratio = 1.44, 95% confidence interval 1.10, 1.91). This difference was not accounted for by an older age when attempting to become pregnant among the RA cases compared with the controls. The result was unrelated to rheumatoid factor or HLA-DR4 status.
CONCLUSION
Women with RA were found to have decreased fecundity prior to disease onset, compared with control women.
目的
研究类风湿关节炎（RA）女性患者发病前的生育能力。
方法
作为一项关于女性近期发病RA的前瞻性病例对照研究的一部分，将259例有怀孕机会的RA患者与1258例对照女性进行比较。
结果
42%的RA病例怀孕间隔为12个月或更长时间，而对照女性为34%（优势比=1.44，95%置信区间1.10，1.91）。与对照组相比，RA病例在尝试怀孕时年龄较大并不能解释这种差异。该结果与类风湿因子或HLA-DR4状态无关。
结论
与对照女性相比，发现RA女性在疾病发病前生育能力下降。
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