类风湿关节炎女性患者中与疾病发病年龄相关的DR4患病率。
DR4 prevalence related to the age at disease onset in female patients with rheumatoid arthritis.
作者信息
Hazes J M, Dijkmans B A, Hoevers J M, Janson J J, de Vries R R, Vandenbroucke J P, Cats A
机构信息
Department of Rheumatology, University Hospital Leiden, The Netherlands.
出版信息
Ann Rheum Dis. 1989 May;48(5):406-8. doi: 10.1136/ard.48.5.406.
Abstract
The prevalence of HLA-DR4 in relation to age at disease onset was calculated in 226 consecutive female patients with definite or classical rheumatoid arthritis (RA). A slight increase in the prevalence of DR4 with age at RA onset was found. This appeared to be due to the low percentage of rheumatoid factor (RF) positivity in the youngest age groups; the DR4 prevalence in the RF positive patients was constant for all decades--that is, approximately 60%. A previously reported declining trend of DR4 prevalence in women with RA in relation to age of RA onset may be due to the disease heterogeneity of the patients included in that study.
摘要
在226例连续的确诊或典型类风湿关节炎（RA）女性患者中，计算了HLA - DR4患病率与疾病发病年龄的关系。发现DR4患病率随RA发病年龄略有增加。这似乎是由于最年轻年龄组类风湿因子（RF）阳性率较低；RF阳性患者中DR4患病率在所有年龄段均保持恒定——即约60%。先前报道的RA女性患者中DR4患病率随RA发病年龄下降的趋势，可能是由于该研究中纳入患者的疾病异质性所致。
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本文引用的文献
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