Palumbo P J, Briones E R, Nelson R A, Kottke B A
Am J Clin Nutr. 1977 Mar;30(3):394-401. doi: 10.1093/ajcn/30.3.394.
Various loads of simple carbohydrates were fed to 148 patients with known coronary-artery disease (CAD) for 4 days in the Clinical Research Center. The 148 patients were grouped according to the diet regimen tested-sucrose (low and high), glucose, and fructose. A high-sucrose diet was fed to 29 control subjects. Diets containing 2 g of simple carbohydrate (predominantly either sucrose or glucose) per kilogram of body weight per day had no significant effect on fasting plasma glucose, serum triglycerides, or serum free fatty acids. However, diets containing 4 g of simple carbohydrate (predominantly sucrose) or 2 g fructose per kilogram of body weight per day produced a significant rise in serum triglycerides with decreases in fasting plasma glucose and free fatty acids. Serum cholesterol diminished in all the diet groups, probably because of the decrease fat and cholesterol intakes. The increase of serum triglycerides in CAD patients receiving simple carbohydrate at the 4-g/kg rate was significantly greater than in the normal control subjects fed the same diet, suggesting a sensitivity of CAD patients to this stimulus. No significant correlation could be demonstrated between changes in serum triglycerides and the extent of CAD (one, two, or three vessels) as determined from coronary angiograms.
在临床研究中心，对148例已知患有冠状动脉疾病（CAD）的患者给予不同负荷的简单碳水化合物，为期4天。这148例患者根据所测试的饮食方案进行分组——蔗糖（低和高）、葡萄糖和果糖。给29名对照受试者喂食高蔗糖饮食。每天每千克体重含2克简单碳水化合物（主要是蔗糖或葡萄糖）的饮食对空腹血糖、血清甘油三酯或血清游离脂肪酸没有显著影响。然而，每天每千克体重含4克简单碳水化合物（主要是蔗糖）或2克果糖的饮食会使血清甘油三酯显著升高，同时空腹血糖和游离脂肪酸降低。所有饮食组的血清胆固醇均降低，可能是由于脂肪和胆固醇摄入量减少。以4克/千克的速率接受简单碳水化合物的CAD患者血清甘油三酯的升高显著大于喂食相同饮食的正常对照受试者，这表明CAD患者对这种刺激敏感。从冠状动脉血管造影确定的血清甘油三酯变化与CAD的程度（单支、双支或三支血管）之间未显示出显著相关性。
