Konturek S J, Domschke S, Domschke W, Wünsch E, Demling L
Am J Physiol. 1977 Feb;232(2):E156-8. doi: 10.1152/ajpendo.1977.232.2.E156.
This study was designed to compare pancreatic bicarbonate responses to secretin and vasoactive intestinal peptide (VIP) administered either by peripheral or portal route in 24 anesthetized cats. Continuous intravenous infusion of graded doses of secretin (rang from 0.04 to 0.68 nmol/kg per h), stimulated pancreatic volume flow and bicarbonate outputs dose dependently and not statistically differently when given into the peripheral or portal vein. VIP infused in graded doses (range from 0.60 to 9.62 nmol/kg per h) into the peripheral vein produced pancreatic volume flow and bicarbonate outputs not statistically different from those obtained with secretin. In contrast, the biological activity of VIP administered intraportally was reduced by 60% at lower VIP doses (0.60 and 1.20 nmol/kg per h) and by 40% at 2.40 nmol/kg per h, whereas at higher doses it was not significantly changed. This study provides evidence that VIP in the cat is a secretin-like full agonist of pancreatic bicarbonate secretion and that it is only partially inactivated by the liver.
本研究旨在比较24只麻醉猫经外周或门静脉途径给予促胰液素和血管活性肠肽（VIP）后胰腺碳酸氢盐的反应。持续静脉输注不同剂量的促胰液素（0.04至0.68纳摩尔/千克每小时），无论经外周静脉还是门静脉给药，均能剂量依赖性地刺激胰腺体积流量和碳酸氢盐分泌量，且在统计学上无显著差异。以不同剂量（0.60至9.62纳摩尔/千克每小时）经外周静脉输注VIP，所产生的胰腺体积流量和碳酸氢盐分泌量与促胰液素所产生的无统计学差异。相比之下，经门静脉给予较低剂量（0.60和1.20纳摩尔/千克每小时）的VIP时，其生物活性降低60%，给予2.40纳摩尔/千克每小时时降低40%，而较高剂量时则无显著变化。本研究提供了证据表明，猫体内的VIP是胰腺碳酸氢盐分泌的类促胰液素完全激动剂，且仅部分被肝脏灭活。
