Renard G, Bennani N, Lutaj P, Richard C, Trinquand C
Ophthalmology Department, Hôtel-Dieu de Paris, France.
J Cataract Refract Surg. 1993 Jan;19(1):48-51. doi: 10.1016/s0886-3350(13)80280-5.
To compare the effectiveness of subconjunctival injections and collagen shields in delivering anti-inflammatory agents and antibiotics after cataract surgery, we conducted a prospective study of 61 patients. They were randomly assigned to three groups: subconjunctival injection of gentamicin and dexamethasone; the same route plus a collagen shield without drug; collagen shield soaked in gentamicin and dexamethasone. All subjects had a manual extracapsular cataract extraction with posterior chamber intraocular lens implantation. Eyes were evaluated at the end of surgery and 24 hours later. The collagen shield achieved a progressive effect on pain and a decrease in conjunctival redness after 24 hours. The occurrence of folds in Descemet's membrane was less frequent and aqueous flare less severe than when subconjunctival injections were used. No adverse effect was reported. We conclude that the collagen shield could be a safe, better, noninvasive technique because of its double action of bandage and enhancement of drug penetration.
为比较白内障手术后结膜下注射与胶原盾在递送抗炎药物和抗生素方面的有效性，我们对61例患者进行了一项前瞻性研究。他们被随机分为三组：结膜下注射庆大霉素和地塞米松；相同给药途径加不含药物的胶原盾；浸泡在庆大霉素和地塞米松中的胶原盾。所有受试者均接受了手法白内障囊外摘除联合后房型人工晶状体植入术。在手术结束时和24小时后对眼睛进行评估。胶原盾在术后24小时对疼痛有渐进性作用，并可减轻结膜充血。与结膜下注射相比，Descemet膜褶皱的发生率较低，房水闪光也较轻。未报告不良反应。我们得出结论，胶原盾因其具有绷带作用和增强药物渗透的双重作用，可能是一种安全、更好的非侵入性技术。
